Macrophage migration inhibitory factor may play a protective role in osteoarthritis

Xie, Zhongjian; Sun, Guang; Chen, L.; Liu, M.; Qi, Dake; Furey, Andrew; Rahman, Proton; Lei, Guang; Zhai, Guangju

doi:10.1016/j.joca.2020.02.199

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“…Macrophage migration inhibitory factor (MIF) is a procytokine that mediates inflammatory pleiotropic effects in selected neoplasms and inflammatory diseases (rheumatoid arthritis and ankylosing spondylitis). The role of MIF in OA, however, has yet to be stated (Xie et al 2020). The present study aimed at exploring the relationship between VDR single-nucleotide polymorphisms (VDR-SNPs) (ApaI rs7975232 and TaqI rs731236) and knee OA(KOA) in Egyptian patients and investigating the serum and synovial levels of inflammatory cytokines (TNF-α and MIF) and vitamin D status among these patients.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status

et al. 2021

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Osteoarthritis (OA) etiology and pathogenesis not yet fully understood. We studied the role of vitamin D receptor single-nucleotide polymorphisms (VDR-SNPs), vitamin D3, serum and synovial macrophage migration inhibitory factor (MIF), and tumor necrosis factor-α (TNF-α) in the development and progression of knee OA (KOA). This study included 205 Egyptian subjects (105 patients with KOA and 100 unrelated, healthy matched subjects selected as controls). The patient group was divided into three groups according to KOA severity (mild, moderate, and severe), with 35 patients in each group. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used for the ApaI and TaqI SNPs. Vitamin D, serum and synovial TNF-α, and MIF assays were performed using ELISA kits. There were significantly lower serum levels of 25-hydroxycholecalciferol with significant increasing TNF-α and MIF levels in relation to disease severity among the cases (all: p˂0.05).Wild homozygous and heterozygous mutant genotypes (GG+GT) and G allele of ApaI demonstrated risk for KOA development, with odds ratio OR = 6.313 (95% confidence interval (CI) 2.074-19.210) and OR = 1.532 (95%CI 1.013-2.317), respectively. Homozygous mutant CC genotype and C allele of TaqI could be considered a risk factor associated with KOA development, with OR = 2.667 (95%CI 1.270-5.601) and OR = 0.737 (95%CI 0.496-1.095), respectively. VDR-SNPs, vitamin D3, TNF-α, and MIF could play an essential role in the pathogenesis and progression of KOA with mechanistic associations.

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Section: Introductionmentioning

confidence: 99%