2019
DOI: 10.1002/ppul.24262
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Nocardia spp is a gram-positive aerobic filamentous bacteria that causes pulmonary and systemic infections, especially in patients with immunosuppression or chronic lung diseases.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
5
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(5 citation statements)
references
References 13 publications
0
5
0
Order By: Relevance
“…Although full biochemical and clinical examination is not documented in these cases, some of the pathophysiology of ‘cepacia syndrome’ may potentially explained by unrecognised MAS/HLH; the cornerstone of treatment of MAS/HLH is aggressive eradication of the triggering event (such as infection or malignancy) if possible, glucocorticosteroids, high dose IVIG and ciclosporin with or without etoposide. Confirmed ‘MAS/HLH’ in CF patients secondary to B. cepacia has not been described in the literature to our knowledge, although cases due to other organisms exist 27 28…”
Section: Discussionmentioning
confidence: 89%
“…Although full biochemical and clinical examination is not documented in these cases, some of the pathophysiology of ‘cepacia syndrome’ may potentially explained by unrecognised MAS/HLH; the cornerstone of treatment of MAS/HLH is aggressive eradication of the triggering event (such as infection or malignancy) if possible, glucocorticosteroids, high dose IVIG and ciclosporin with or without etoposide. Confirmed ‘MAS/HLH’ in CF patients secondary to B. cepacia has not been described in the literature to our knowledge, although cases due to other organisms exist 27 28…”
Section: Discussionmentioning
confidence: 89%
“…Only two cases of secondary HLH have been described in patients with CF so far 2,3 . We report a third case in a boy with CF during adenovirus infection.…”
Section: Introductionmentioning
confidence: 76%
“…Our patient had a rapid response to first‐line treatment with steroid therapy and IVIG. Steroid treatment alone was performed successfully in the other two reported cases, both triggered by an acute infection (H1N1 influenza A virus 2 and Nocardia spp 3 ). Epstein‐Barr virus and cytomegalovirus have also been recognized as triggers for secondary HLH.…”
Section: Discussionmentioning
confidence: 95%
“…Secondary HLH may complicate different systemic diseases, most frequently infections. Cases of secondary HLH have been described in three patients with CF and were, respectively, induced by Nocardia, A/H1N1 influenza, and Adenovirus 31‐33 . It is interesting to note that BCC septicemia and macrophage activation syndrome (MAS)/HLH are rare but well‐known complications of chronic granulomatous disease (CGD) and four cases triggered by BCC have previously been described in this context 34‐36 .…”
Section: Discussionmentioning
confidence: 99%
“…in three patients with CF and were, respectively, induced by Nocardia, A/H1N1 influenza, and Adenovirus. [31][32][33] It is interesting to note that BCC septicemia and macrophage activation syndrome (MAS)/HLH are rare but well-known complications of chronic granulomatous disease (CGD) and four cases triggered by BCC have previously been described in this context. [34][35][36] Some of the pathophysiology of CS could potentially be compared to unrecognized MAS/HLH.…”
Section: Discussionmentioning
confidence: 99%