Macromol. Biosci. 8/2013

Schneider, Julian; Bachmann, Tobias; Franco, Davide; Richner, Patrizia; Galliker, Patrick; Tiwari, Manish K.; Ferrari, Aldo; Poulikakos, Dimos

doi:10.1002/mabi.201370025

Cited by 5 publications

(10 citation statements)

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“…The drug-likeness properties were evaluated by Pfizer's rule (also called as Lipinski's rule), wherein it states that those candidates that have values of log P ≤ 5, HBD ≤ 5, HBA ≤ 10, MW ≤ 500, TPSA (<140), and AMR (40–130), are considered to have passed the drug-likeness analysis [ 37 ]. These above parameters influence the bioavailability, absorption, receptor-drug interactions, metabolism and their toxicity [ 56 ]. The size of the molecule is also an important factor for drug candidates and it is useful for membrane transportation [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study

Murugesan

Kottekad

Crasta

et al. 2021

Computers in Biology and Medicine

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Coronavirus Disease-2019 (COVID-19), a viral disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a global pandemic by WHO in 2020. In this scenario, SARS-CoV-2 main protease (COVID-19 M pro ), an enzyme mainly involved in viral replication and transcription is identified as a crucial target for drug discovery. Traditionally used medicinal plants contain a large amount of bioactives and pave a new path to develop drugs and medications for COVID-19. The present study was aimed to examine the potential of Emblica officinalis (amla), Phyllanthus niruri Linn. (bhumi amla) and Tinospora cordifolia (giloy) bioactive compounds to inhibit the enzymatic activity of COVID-19 M pro . In total, 96 bioactive compounds were selected and docked with COVID-19 M pro and further validated by molecular dynamics study. From the docking and molecular dynamics study, it was revealed that the bioactives namely amritoside, apigenin-6-C-glucosyl7-O-glucoside, pectolinarin and astragalin showed better binding affinities with COVID-19 M pro . Drug-likeness, ADEMT and bioactivity score prediction of best drug candidates were evaluated by DruLiTo, pkCSM and Molinspiration servers, respectively. Overall, the in silico results confirmed that the validated bioactives could be exploited as promising COVID-19 M pro inhibitors.

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Section: Resultsmentioning

confidence: 99%

Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study

Murugesan

Kottekad

Crasta

et al. 2021

Computers in Biology and Medicine

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“…The normalized H data should be treated with corresponding care, although we tried to select a value that is most representative of the available literature. References for literature data: EHDP, [42] LAEPD, [43] LIFT (ink), [47,78,79] MCED, [26,51] FluidFM, [54] EHD-RP, [57] FEBID. [22,[59][60][61][62] *: Pt nanoparticles embedded in a carbonaceous matrix.…”

Section: Limitations Of the Study And Validity And General Applicability Of The Resultsmentioning

confidence: 99%

“…), [41] 6 (ann.) [42] 0. LAEPD -Laser-assisted electrophoretic deposition of nanoparticles [43] Au 1.5 (ad.)…”

Section: Overview Of Included Am Methods and Samplesmentioning

confidence: 99%

Metals by Micro‐Scale Additive Manufacturing: Comparison of Microstructure and Mechanical Properties

Reiser

Koch

Dunn

et al. 2020

Adv Funct Materials

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Many emerging applications in microscale engineering rely on the fabrication of 3D architectures in inorganic materials. Small-scale additive manufacturing (AM) aspires to provide flexible and facile access to these geometries. Yet, the synthesis of device-grade inorganic materials is still a key challenge toward the implementation of AM in microfabrication. Here, a comprehensive overview of the microstructural and mechanical properties of metals fabricated by most state-of-the-art AM methods that offer a spatial resolution ≤10 μm is presented. Standardized sets of samples are studied by cross-sectional electron microscopy, nanoindentation, and microcompression. It is shown that current microscale AM techniques synthesize metals with a wide range of microstructures and elastic and plastic properties, including materials of dense and crystalline microstructure with excellent mechanical properties that compare well to those of thin-film nanocrystalline materials. The large variation in materials' performance can be related to the individual microstructure, which in turn is coupled to the various physico-chemical principles exploited by the different printing methods. The study provides practical guidelines for users of small-scale additive methods and establishes a baseline for the future optimization of the properties of printed metallic objects-a significant step toward the potential establishment of AM techniques in microfabrication.

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“…15,16 It has been used to deposit inks containing colloidal nanomaterials, 15,16 polymers 17,18 and biomaterials 19 with femto-to attoliter volumes and has been applied to the field of flexible electronics [20][21][22][23] and biotechnology. 24,25 In addition to using EHD printing to write functional micro-and nanostructures, it was recently shown that the EHD nanodripping mode is able to generate and sustain ultra-small droplets under an open atmosphere on non-wetting surfaces. 26 In this work, we combine the open atmosphere printing capability of EHD nanodripping with a novel ink chemistry and the generation of sessile droplets acting as attoliter reactors to advance the status of site-specific particle deposition to the level of printing single nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Site-specific deposition of single gold nanoparticles by individual growth in electrohydrodynamically-printed attoliter droplet reactors

et al. 2015

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Gold nanoparticles with unique electronic, optical and catalytic properties can be efficiently synthesized in colloidal suspensions and are of broad scientific and technical interest and utility. However, their orderly integration on functional surfaces and devices remains a challenge. Here we show that single gold nanoparticles can be directly grown in individually printed, stabilized metal-salt ink attoliter droplets, using a nanoscale electrohydrodynamic printing method with a stable high-frequency dripping mode. This enables controllable sessile droplet nanoreactor formation and sustenance on non-wetting substrates, despite simultaneous rapid evaporation. The single gold nanoparticles can be formed inside such reactors in situ or by subsequent thermal annealing and plasma ashing. With this non-contact technique, single particles with diameters tunable in the range of 5-35 nm and with narrow size distribution, high yield and alignment accuracy are generated on demand and patterned into arbitrary arrays. The nanoparticles feature good catalytic activity as shown by the exemplary growth of silicon nanowires from the nanoparticles and the etching of nanoholes by the printed nanoparticles.

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Macromol. Biosci. 8/2013

Cited by 5 publications

References 0 publications

Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study

Targeting COVID-19 (SARS-CoV-2) main protease through active phytocompounds of ayurvedic medicinal plants – Emblica officinalis (Amla), Phyllanthus niruri Linn. (Bhumi Amla) and Tinospora cordifolia (Giloy) – A molecular docking and simulation study

Metals by Micro‐Scale Additive Manufacturing: Comparison of Microstructure and Mechanical Properties

Site-specific deposition of single gold nanoparticles by individual growth in electrohydrodynamically-printed attoliter droplet reactors

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