2013
DOI: 10.18632/aging.100547
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Abstract: Macromitophagy controls mitochondrial quality and quantity. It involves the sequestration of dysfunctional or excessive mitochondria within double-membrane autophagosomes, which then fuse with the vacuole/lysosome to deliver these mitochondria for degradation. To investigate a physiological role of macromitophagy in yeast, we examined how the atg32Δ-dependent mutational block of this process influences the chronological lifespan of cells grown in a nutrient-rich medium containing low (0.2%) concentration of gl… Show more

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Cited by 57 publications
(83 citation statements)
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References 81 publications
(153 reference statements)
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“…S3). [7][8][9][10][11][12][13][14][15] Other PL classes (such as PE and CL) are known to be formed only in the inner mitochondrial membrane (IMM); PE is then transported from mitochondria to the ER via mitochondria-ER junctions and from the ER to the PM via PM-ER junctions (Fig. S3).…”
Section: Resultsmentioning
confidence: 99%
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“…S3). [7][8][9][10][11][12][13][14][15] Other PL classes (such as PE and CL) are known to be formed only in the inner mitochondrial membrane (IMM); PE is then transported from mitochondria to the ER via mitochondria-ER junctions and from the ER to the PM via PM-ER junctions (Fig. S3).…”
Section: Resultsmentioning
confidence: 99%
“…1 To further verify our hypothesis, we examined how various single-gene-deletion mutations (each eliminating an enzyme involved in POA transport to the ER or in POA incorporation into PL and/or NL within the ER; see refs. [7][8][9][10][11][12][13][14][15][16][17][18] and Fig. S3) influence the susceptibility of yeast to POA-induced liponecrotic PCD.…”
Section: -15mentioning
confidence: 96%
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