Infectious Disease Clinics of North America volume 23, issue 4, P997-1026 2009 DOI: 10.1016/j.idc.2009.06.013 View full text
Jerry M. Zuckerman, Fozia Qamar, Bartholomew R. Bono

Abstract: The advanced macrolides, azithromycin and clarithromycin, and the ketolide, telithromycin, are structural analogs of erythromycin. They have several distinct advantages when compared with erythromycin, including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once-daily administration, and improved tolerability. Clarithromycin and azithromycin are used extensively for the treatment of respiratory tract infections, sexually transmitted diseases, and Helicobacter pylori-assoc…

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