Infectious Disease Clinics of North America volume 18, issue 3, P621-649 2004 DOI: 10.1016/j.idc.2004.04.010 View full text
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Jerry M Zuckerman

Abstract: The advanced macrolides, azithromycin and clarithromycin, and the ketolide telithromycin are structural analogues of erythromycin. They have several distinct advantages when compared with erythromycin including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once daily administration, and improved tolerability. This article reviews the pharmacokinetics, antimicrobial activity, clinical use, and adverse effects of these antimicrobial agents.