Macrocyclic metal complexes: synthesis and characterization of 14- and 16- membered tetraaza macrocyclic complexes of transition metals

Singh, Ashok Kumar; Singh, Rupam; Saxena, Puja

doi:10.1007/s11243-004-1732-0

Cited by 40 publications

(14 citation statements)

References 11 publications

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“…A strong absorption band in the region ca. 1615-1655 cm )1 may be attributed to the C=N group [2,19]. The lower values of m(C=N) may be explained on the basis of drift of a lone pair density of azomethine nitrogen towards the metal atom [17,20].…”

Section: Ir Spectramentioning

confidence: 98%

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Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil

Singh

Kumar

Tyagi

2006

Transition Met Chem

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A novel series of complexes of the type [M(TML)X 2 ]; where TML is a tetradentate macrocyclic ligand; M = Co(II), Ni(II), Cu(II) or Zn(II); X = Cl ) , CH 3 COO ) or NO 3 ) have been synthesized by template condensation of benzil and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized with the help of elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest the six coordinate octahedral geometry for these complexes. The low value of molar conductance indicates them to be non-electrolytes. The biological activities of metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential.

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Section: Ir Spectramentioning

confidence: 98%

“…Macrocycles have been studied extensively and are best prepared by the aid of metal ions as templates to direct the condensation reaction towards ring closure [2]. A number of nitrogen donor macrocyclic derivatives have long been used in analytical, industrial and medical applications [3].…”

Section: Introductionmentioning

confidence: 99%

Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil

Singh

Kumar

Tyagi

2006

Transition Met Chem

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“…This confirms the condensation of carbonyl groups of isatin and amino groups of ethylenediamine 13,14 . This fact is also supported by the appearance of a new strong absorption band in the region ∼1590-1615 cm −1 , which may be attributed to ν(C=N) 15,16 . These results provide strong evidence for the formation of the macrocyclic frame 17 .…”

Section: Infrared Spectramentioning

confidence: 64%

Template synthesis of macrocyclic complexes and their spectroscopic and antibacterial studies

Singh

Grover

Kumar

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…The condensation of carbonyl groups and amino groups [12,13] and the assembly of macrocyclic Schiff's base [11] is further supported by presence of a new strong absorption band in the region 1615-1590 cm -1 . This may be attributed due to ν(C=N) [14,15].…”

Section: Resultsmentioning

confidence: 99%

Template Engineered Tetraazamacrocyclic Complexes and their Antibacterial Studies

Kamboj¹,

Jain²,

Singh³

2018

Asian J. Chem.

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INTRODUCTIONMacrocyclic metal complexes are marvelous molecules due to their capability to bind different kinds of ligands. They play dominant role in bioinorganic chemistry for their many applications. The interest for these nitrogen containing macrocycles analogs is due to their analytical, industrial and medical applications [1]. Antiviral, anticarcinogenic [2] as well as antifertile [3] biological activities of macrocyclic complexes have gained the curiosity and has now been an emergent research area. Macrocyclic complexes also find useful place as MRI contrast agents [4,5].Research on designing new Gd coordination complexes has amplified since the approval of [Gd(DTPA)(H 2 O)] 2 [6]. These multiple applications of macrocyclic complexes have been the driving force for their rapid growth during the last two decades. Macrocyclic compounds are studied for various reasons: (i) they are relevant to the active centers of metalloenzymes; (ii) they are used as industrial catalysts; (iii) used as models for proteinmetal binding sites in biological systems; (iv) as sequestering reagents for specific metal ions; (v) as models to study the magnetic exchange phenomena; (vi) as chemical sensors and batteries; (vii) as therapeutic reagents for the treatment of metal intoxication; and (viii) as medical imaging agents and in biomedical and fuel cell applications.Diverse oxidation states are exhibited by transition metals and these can be organized with number of ligand. Hence, it has essential position within medicinal inorganic chemistry.

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Macrocyclic metal complexes: synthesis and characterization of 14- and 16- membered tetraaza macrocyclic complexes of transition metals

Cited by 40 publications

References 11 publications

Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil

Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil

Template synthesis of macrocyclic complexes and their spectroscopic and antibacterial studies

Template Engineered Tetraazamacrocyclic Complexes and their Antibacterial Studies

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