Machine learning identifies “rsfMRI epilepsy networks” in temporal lobe epilepsy

Abstract

Objectives Experimental models have provided compelling evidence for the existence of neural networks in temporal lobe epilepsy (TLE). To identify and validate the possible existence of resting-state "epilepsy networks," we used machine learning methods on resting-state functional magnetic resonance imaging (rsfMRI) data from 42 individuals with TLE. Methods Probabilistic independent component analysis (PICA) was applied to rsfMRI data from 132 subjects (42 TLE patients + 90 healthy controls) and 88 independent components (ICs) were obtained following standard procedures. Elastic net-selected features were used as inputs to support vector machine (SVM). The strengths of the top 10 networks were correlated with clinical features to obtain "rsfMRI epilepsy networks." Results SVM could classify individuals with epilepsy with 97.5% accuracy (sensitivity = 100%, specificity = 94.4%). Ten networks with the highest ranking were found in the frontal, perisylvian, cingulo-insular, posterior-quadrant, thalamic, cerebellothalamic, and temporo-thalamic regions. The posterior-quadrant, cerebello-thalamic, thalamic, medial-visual, and perisylvian networks revealed significant correlation (r > 0.40) with age at onset of seizures, the frequency of seizures, duration of illness, and a number of anti-epileptic drugs. Conclusions IC-derived rsfMRI networks contain epilepsy-related networks and machine learning methods are useful in identifying these networks in vivo. Increased network strength with disease progression in these "rsfMRI epilepsy networks" could reflect epileptogenesis in TLE. Key Points• ICA of resting-state fMRI carries disease-specific information about epilepsy.• Machine learning can classify these components with 97.5% accuracy.• "Subject-specific epilepsy networks" could quantify "epileptogenesis" in vivo.

Magnetic resonance-guided focused ultrasound for mesial temporal lobe epilepsy: a case report

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“…Further investigations can explore other shift‐invariant techniques with a narrower range of frequency bands. Moreover, researchers have long studied the implications of functional connectivity networks and epileptogenic regions [36–38, 39]. Building on the foundation provided by this Letter thus far would lead to better automated detection of epileptiform patterns and thus data confined to epileptiform stages would, in turn, usher better localisation of seizure foci and study its spatiotemporal connections.…”