“…A number of studies have shown that PLA2G4A (placental phospholipase A24A is involved in the biological procedure of stress response in various diseases (Brien et al, 2017;Zhang et al, 2018;Mishra et al, 2022). PLA2G4A is overexpressed in different solid cancers such as hepatocellular carcinoma (Fu et al, 2017), prostate cancer (Patel et al, 2008), breast cancer (Chen et al, 2017), cervical cancer (Xu et al, 2019), as well as malignant hematologic diseases, such as AML (acute myeloid leukemia) (Runarsson et al, 2007;Bai et al, 2020;Zhang et al, 2022) In multiple myeloma patients, expression of the PLA2G4A was higher compared to healthy individuals and high gene expression of PLA2G4A is associated with adverse outcomes Frontiers in Genetics frontiersin.org (Mahammad et al, 2021). A previous study showed that FOXO1 (Forkhead Box O1) activation could inhibit the tumor growth and induce cell autophagy and cell death.…”