volume 83, issue 1, P153-168 2014
DOI: 10.1002/prot.24714
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Abstract: AbstractThe epidermal growth factor receptor (EGFR) is an important target in the treatment of cancer. A very potent antibody, mAb806, has been developed against overexpressed EGFR and was found to be particularly active in brain tumours. Structural studies reveal that it binds an epitope on the extracellular region of the EGFR. However, this epitope is cryptic / buried in crystal structures of the active (untethered) and inactive (tethered) EGFR and it is unclear as to how the antibody interacts with this re…

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