2013
DOI: 10.1038/nn.3469
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The lack of therapies for progressive multiple sclerosis highlights the need to understand the regenerative process of remyelination that can follow CNS demyelination. This involves an innate immune response consisting of microglia/macrophages, which can be polarized to distinct functional phenotypes: proinflammatory (M1) or anti-inflammatory/immunoregulatory (M2). Here we show that a switch from an M1-to M2-dominant response occurred within microglia and peripherally-derived macrophages as remyelination start… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

57
1,290
6
6

Year Published

2015
2015
2023
2023

Publication Types

Select...
5
4

Relationship

0
9

Authors

Journals

citations
Cited by 1,361 publications
(1,359 citation statements)
references
References 48 publications
57
1,290
6
6
Order By: Relevance
“…5A). In the presence of growth factors‐free medium most OPCs either differentiate in oligodendrocytes or die by apoptosis (Miron et al, 2013). Following withdrawal of growth factors for 4 days, we found a similar number of TUNEL + cells but a twofold increase of MBP + /Olig2 + mature oligodendrocytes in cultures derived from P301S‐htau mice compared with those from Wt mice (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…5A). In the presence of growth factors‐free medium most OPCs either differentiate in oligodendrocytes or die by apoptosis (Miron et al, 2013). Following withdrawal of growth factors for 4 days, we found a similar number of TUNEL + cells but a twofold increase of MBP + /Olig2 + mature oligodendrocytes in cultures derived from P301S‐htau mice compared with those from Wt mice (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Similar microglial clustering is frequently found in early stages of MS white matter in the absence of demyelination, but associated with axonal injury identified as accumulation of APP and non‐phosphorylated neurofilament (Singh et al, 2013). To note, an inflammatory microenvironment is essential for an efficient remyelination, for example for the removal of myelin debris from the demyelinated lesions (Kotter et al, 2005; Miron et al, 2013; Ruckh et al, 2012). Importantly, the cytokines IL‐1β and TNFα, which are upregulated in young P301S‐htau mice compared with Wt mice (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, CD11c‐positive microglial cells were described as a major source of IGF1 to support developmental OL myelination (Wlodarczyk et al, 2017). Moreover, M2‐type microglia and blood‐derived macrophages were shown to promote remyelination by secreting activin‐A, potentially contributing to mTORC1 activation in OL‐lineage cells (Miron et al, 2013). On a more speculative note, analogously to neurons, the PI3K‐Akt‐mTORC1 signaling might also be involved in the production and release of myelination‐regulating growth factors by astrocytes and microglia.…”
Section: Myelination and Mtormentioning
confidence: 99%
“…In fact, a recent study reported that M2-microglia produced activin-A to drive oligodendrocyte differentiation. 88 Notably, aging can affect the switch from M1 to M2 phenotype in microglia, and this delay in the M1-to-M2 transition may correlate to the disturbance of OPC differentiation. 88 …”
Section: Oligodendrocyte-astrocyte/microglia Interactionmentioning
confidence: 99%