2013
DOI: 10.18632/aging.100580 View full text |Buy / Rent full text
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Abstract: A recent ground-breaking publication described hypothalamus-driven programmatic aging. As a Russian proverb goes “everything new is well-forgotten old”. In 1958, Dilman proposed that aging and its related diseases are programmed by the hypothalamus. This theory, supported by beautiful experiments, remained unnoticed just to be re-discovered recently. Yet, it does not explain all manifestations of aging. And would organism age without hypothalamus? Do sensing pathways such as MTOR (mechanistic Target of Rapamyc… Show more

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“…mTOR is the central nutrient sensor that coordinates the various upstream signaling and environmental stimuli to regulate cell growth and fate [83]. mTOR is the key molecule that regulates cancer growth and the process of aging both in the presence or absence of CR [37].…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…mTOR is the central nutrient sensor that coordinates the various upstream signaling and environmental stimuli to regulate cell growth and fate [83]. mTOR is the key molecule that regulates cancer growth and the process of aging both in the presence or absence of CR [37].…”
Section: Discussionmentioning
“…An increasing number of experimental data suggest that aging in evolutionary distant model organisms, such as nematodes, fruit flies, and some mammals, is regulated through evolutionary conserved signaling pathways such as the insulin/IGF-1 pathway (Kenyon 2011) and mTOR (Blagosklonny 2012), which stands for "mammalian target of rapamycin", formally referred to as "mechanistic target of rapamycin" (MTOR), informally known as the "M(o)TOR of aging", and biochemically described as serine/threonine kinase (Hands et al 2009;Kapahi et al 2009;Katewa and Kapahi 2011;Sharp 2011;Kaeberlein and Martin 2016). Based on this, the theory of hyperfunction has been latterly formulated, including the important mTOR quasi-program rival to the DST, offering a completely different approach to numerous problems and paradoxes in current biogerontology, and allowing the prediction of completely new relationships (Blagosklonny 2008;2009;2010a;2010b;2013a;2013b;2013c;2013d;2013e;2013f). However, there were also some controversies.…”
Section: Introductionmentioning
“…Yet, the unusual enrichment of these pathways in yeast and worms definitely highlights their importance in determination of longevity for these taxa specifically. For vertebrates, we found a significant enrichment in Neuroactive ligand-receptor interaction, which could reflect the importance of neuroendocrine regulation of aging and longevity in higher organisms (Dilman et al 1986; Frolkis 1988; Blagosklonny 2013).…”
Section: Resultsmentioning