Lyssavirus-reactive antibodies in Swedish bats

Hammarin, Anna-Lena; Berndtsson, Louise Treiberg; Falk, Kerstin I.; Nedinge, Marie; Olsson, Gert E.; Lundkvist, Åke

doi:10.3402/iee.v6.31262

Cited by 10 publications

(13 citation statements)

References 32 publications

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“…Approximately 735 dead bats were submitted for rabies diagnosis from 1986 to 2017, and all were found negative by FAT and/or RT-PCR, consistent with reports from several European countries and dependent on number of samples tested [ 19 – 21 ]. Additionally, most tested bats were found dead by bat biologists and were in different stages of decomposition.…”

Section: Discussionsupporting

confidence: 73%

Molecular and serological survey of lyssaviruses in Croatian bat populations

et al. 2018

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BackgroundRabies is the only known zoonotic disease of bat origin in Europe. The disease is caused by species belonging to the genus Lyssavirus. Five Lyssavirus species, i.e., European bat lyssavirus (EBLV)-1, EBLV-2, Bokeloh bat lyssavirus, Lleida bat lyssavirus, and West Caucasian bat virus, have been identified in European bats. More recently, a proposed sixth species, Kotalahti bat lyssavirus, was detected. Thus, in this study, active surveillance was initiated in order to obtain insights into the prevalence of lyssaviruses in Croatian bat populations and to improve our understanding of the public health threat of infected bats.ResultsIn total, 455 bats were caught throughout Continental and Mediterranean Croatia. Antibodies were found in 20 of 350 bats (5.71%, 95% confidence interval 3.73–8.66). The majority of seropositive bats were found in Trbušnjak cave (Continental Croatia, Eastern part), and most seropositive bats belonged to Myotis myotis (13/20). All oropharyngeal swabs were negative for the presence of Lyssavirus.ConclusionsThe presence of lyssaviruses in bat populations was confirmed for the first time in Croatia and Southeastern Europe. The results of this study suggest the need for further comprehensive analyses of lyssaviruses in bats in this part of Europe.

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Section: Discussionsupporting

confidence: 73%

Molecular and serological survey of lyssaviruses in Croatian bat populations

et al. 2018

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“…Since temporal fluctuation of viral load has been documented in virus surveillance of north American and European microbats [96,97] as well as Hendra shedding in Australian peteropid bats [22,98], longitudinal studies would be required to fully understand the viral shedding and viral-host associations observed here. Furthermore, evidence of higher viral loads as indicators of individual and population scale stress [10] provides a good example of how long-term monitoring of viral prevalence can act as an indicator of environmental pressure on bat communities, particularly with regards to climate change where habitat contracture and distributional shifts may bring together populations harbouring novel viral strains.…”

Section: Discussionmentioning

confidence: 97%

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Prada

Boyd

Baker

et al. 2019

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Bats are known reservoirs of a wide variety of viruses that rarely result in overt clinical disease in the bat host. However, anthropogenic influences on the landscape and climate can change species assemblages and interactions, as well as undermine host-resilience. The cumulative result is a disturbance of bat-pathogen dynamics, which facilitate spillover events to sympatric species, and may threaten bat communities already facing synergistic stressors through ecological change. Therefore, characterisation of viral pathogens in bat communities provides important basal information to monitor and predict the emergence of diseases relevant to conservation and public health. This study used targeted molecular techniques, serological assays and next generation sequencing to characterise adenoviruses, coronaviruses and paramyxoviruses from 11 species of insectivorous bats within the South West Botanical Province of Western Australia. Phylogenetic analysis indicated complex ecological interactions including virus-host associations, cross-species infections, and multiple viral strains circulating concurrently within selected bat populations. Additionally, we describe the entire coding sequences for five alphacoronaviruses (representing four putative new species), and one novel adenovirus. Results indicate that viral burden (both prevalence and richness) is not homogeneous among species, with Chalinolobus gouldii identified as a key epidemiological element within the studied communities.

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“…Viruses from six lyssavirus species (RABV, EBLV-1, EBLV-2, BBLV, WCBV and LLEBV) have been detected in Europe, of which only EBLV-2 has been detected in the UK. Surveillance for EBLV-2, as part of a wider surveillance for all lyssaviruses, is undertaken in a number of countries across Europe, including Belgium, Denmark, Finland, France, Germany, Italy, The Netherlands, Poland, Spain, Sweden, Switzerland and the UK [6,7]. The methodology and coverage of surveillance varies between countries and it is likely that EBLV-2 cases are underestimated because of this inconsistency, low sensitivity of surveillance and lack of reporting.…”

Section: Introductionmentioning

confidence: 99%

Passive surveillance of United Kingdom bats for lyssaviruses (2005–2015)

et al. 2017

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Passive surveillance for lyssaviruses in UK bats has been ongoing since 1987 and has identified 13 cases of EBLV-2 from a single species; Myotis daubentonii. No other lyssavirus species has been detected. Between 2005 and 2015, 10 656 bats were submitted, representing 18 species, creating a spatially and temporally uneven sample of British bat fauna. Uniquely, three UK cases originate from a roost at Stokesay Castle in Shropshire, England, where daily checks for grounded and dead bats are undertaken and bat carcasses have been submitted for testing since 2007. Twenty per cent of Daubenton's bats submitted from Stokesay Castle since surveillance began, have tested positive for EBLV-2. Phylogenetic analysis reveals geographical clustering of UK viruses. Isolates from Stokesay Castle are more closely related to one another than to viruses from other regions. Daubenton's bats from Stokesay Castle represent a unique opportunity to study a natural population that appears to maintain EBLV-2 infection and may represent endemic infection at this site. Although the risk to public health from EBLV-2 is low, consequences of infection are severe and effective communication on the need for prompt post-exposure prophylaxis for anyone that has been bitten by a bat is essential.

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Lyssavirus-reactive antibodies in Swedish bats

Cited by 10 publications

References 32 publications

Molecular and serological survey of lyssaviruses in Croatian bat populations

Molecular and serological survey of lyssaviruses in Croatian bat populations

Viral Diversity of Microbats within the South West Botanical Province of Western Australia

Passive surveillance of United Kingdom bats for lyssaviruses (2005–2015)

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