Lysophosphatidyl Choline and Cataracts in Uveitis

Lysophosphatidyl choline in the aqueous humour during ocular inflammation.

“…,ugLPC/ml according to Varma and Reddy (1972), 4-3 ,ug according to Cotlier (1976), 1 46 (±0 78) t±g in our experiments. Local increases of phospholipase A and LPC (the former through a likely direct action on membrane phospholipids and the latter acting on the same substrate as a 'detergent') may induce changes in *Part of this article was presented at the Third International Congress for Eye Research, Osaka, Japan, 21-25 May 1978 Correspondence to Professor A. G. Secchi, Istituto di Clinica Oculistica, 35100 Padova, Italy the normal lens permeability.…”

“…(1) Intense uveitis 9-66 1 1 7,ug/ml (2) Mild uveitis 4-13 ±g/ml * From Cotlier et al (1975). t From Secchi et al (1976b) The increased level of LPC in aqueous humour during inflammation may be due to a breakdown of the blood-aqueous barrier for phospholipids (Cotlier et al, 1976). We would point out, however, that an enhanced activity of phospholipase A may be responsible for an increase of lysophosphatidyl choline from cell membrane phosphatidyl choline.…”

“…Changes in LPC levels in a given tissue and/or fluid may thus be considered as an index of changed phospholipase activity. In the anterior chamber of the eye, however, an increase in the LPC level may be due also to the breakdown of a blood-aqueous barrier (Cotlier et al, 1976) specific for phospholipids.…”

Lysophosphatidyl choline in the aqueous humour during ocular inflammation.

“…,ugLPC/ml according to Varma and Reddy (1972), 4-3 ,ug according to Cotlier (1976), 1 46 (±0 78) t±g in our experiments. Local increases of phospholipase A and LPC (the former through a likely direct action on membrane phospholipids and the latter acting on the same substrate as a 'detergent') may induce changes in *Part of this article was presented at the Third International Congress for Eye Research, Osaka, Japan, 21-25 May 1978 Correspondence to Professor A. G. Secchi, Istituto di Clinica Oculistica, 35100 Padova, Italy the normal lens permeability.…”

“…(1) Intense uveitis 9-66 1 1 7,ug/ml (2) Mild uveitis 4-13 ±g/ml * From Cotlier et al (1975). t From Secchi et al (1976b) The increased level of LPC in aqueous humour during inflammation may be due to a breakdown of the blood-aqueous barrier for phospholipids (Cotlier et al, 1976). We would point out, however, that an enhanced activity of phospholipase A may be responsible for an increase of lysophosphatidyl choline from cell membrane phosphatidyl choline.…”

“…Changes in LPC levels in a given tissue and/or fluid may thus be considered as an index of changed phospholipase activity. In the anterior chamber of the eye, however, an increase in the LPC level may be due also to the breakdown of a blood-aqueous barrier (Cotlier et al, 1976) specific for phospholipids.…”

Lens lipids

“……”

Lysophosphatidyl choline in the aqueous humour during ocular inflammation.

“…,ugLPC/ml according to Varma and Reddy (1972), 4-3 ,ug according to Cotlier (1976), 1 46 (±0 78) t±g in our experiments. Local increases of phospholipase A and LPC (the former through a likely direct action on membrane phospholipids and the latter acting on the same substrate as a 'detergent') may induce changes in *Part of this article was presented at the Third International Congress for Eye Research, Osaka, Japan, 21-25 May 1978 Correspondence to Professor A. G. Secchi, Istituto di Clinica Oculistica, 35100 Padova, Italy the normal lens permeability.…”

“…(1) Intense uveitis 9-66 1 1 7,ug/ml (2) Mild uveitis 4-13 ±g/ml * From Cotlier et al (1975). t From Secchi et al (1976b) The increased level of LPC in aqueous humour during inflammation may be due to a breakdown of the blood-aqueous barrier for phospholipids (Cotlier et al, 1976). We would point out, however, that an enhanced activity of phospholipase A may be responsible for an increase of lysophosphatidyl choline from cell membrane phosphatidyl choline.…”

“…Changes in LPC levels in a given tissue and/or fluid may thus be considered as an index of changed phospholipase activity. In the anterior chamber of the eye, however, an increase in the LPC level may be due also to the breakdown of a blood-aqueous barrier (Cotlier et al, 1976) specific for phospholipids.…”

Lens lipids

“……”

Lysophosphatidyl choline in the aqueous humour during ocular inflammation.

“…,ugLPC/ml according to Varma and Reddy (1972), 4-3 ,ug according to Cotlier (1976), 1 46 (±0 78) t±g in our experiments. Local increases of phospholipase A and LPC (the former through a likely direct action on membrane phospholipids and the latter acting on the same substrate as a 'detergent') may induce changes in *Part of this article was presented at the Third International Congress for Eye Research, Osaka, Japan, 21-25 May 1978 Correspondence to Professor A. G. Secchi, Istituto di Clinica Oculistica, 35100 Padova, Italy the normal lens permeability.…”

“…(1) Intense uveitis 9-66 1 1 7,ug/ml (2) Mild uveitis 4-13 ±g/ml * From Cotlier et al (1975). t From Secchi et al (1976b) The increased level of LPC in aqueous humour during inflammation may be due to a breakdown of the blood-aqueous barrier for phospholipids (Cotlier et al, 1976). We would point out, however, that an enhanced activity of phospholipase A may be responsible for an increase of lysophosphatidyl choline from cell membrane phosphatidyl choline.…”

“…Changes in LPC levels in a given tissue and/or fluid may thus be considered as an index of changed phospholipase activity. In the anterior chamber of the eye, however, an increase in the LPC level may be due also to the breakdown of a blood-aqueous barrier (Cotlier et al, 1976) specific for phospholipids.…”

Lens lipids

“……”