Lysine demethylase 1B (Kdm1b) enhances somatic reprogramming through inducing pluripotent gene expression and promoting cell proliferation

Hou, Cuicui; Ye, Zhikai; Yang, Songqin; Jiang, Zhenlong; Wang, Jin; Wang, Erkang

doi:10.1016/j.yexcr.2022.113339

Cited by 2 publications

(2 citation statements)

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“…Also, the study by Hou et al revealed LSD2's potential for reprogramming cancer [34]. KDM1B enhances somatic reprogramming by inducing the expression of pluripotent genes and promoting cell proliferation.…”

Section: Epigenetic Reprogramming Of Cancermentioning

confidence: 99%

“…Role in DNA damage repair in model system [15] Involved in E3 ubiquitin ligase activities, regulating specific genes Role in ubiquitin-mediate proteasomal regulation [29] Implicated in epigenetic reprogramming of cancers HIF-miRNA-LSD2, IFN-I-induced CSCs and reprogramming through pluripotent gene expression [32][33][34] Below are some considerations for studying LSD2. Epigenetic Crosstalk and Inheritance: Examining the interplay between LSD2 and other epigenetic modifiers, such as histone methyltransferases and chromatin remodelers, may uncover complex regulatory networks governing chromatin dynamics.…”

Section: Findings Implicationmentioning

confidence: 99%

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LSD2 Is an Epigenetic Player in Multiple Types of Cancer and Beyond

Kim,

Liu

2024

Biomolecules

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Histone demethylases, enzymes responsible for removing methyl groups from histone proteins, have emerged as critical players in regulating gene expression and chromatin dynamics, thereby influencing various cellular processes. LSD2 and LSD1 have attracted considerable interest among these demethylases because of their associations with cancer. However, while LSD1 has received significant attention, LSD2 has not been recognized to the same extent. In this study, we conduct a comprehensive comparison between LSD2 and LSD1, with a focus on exploring LSD2’s implications. While both share structural similarities, LSD2 possesses unique features as well. Functionally, LSD2 shows diverse roles, particularly in cancer, with tissue-dependent roles. Additionally, LSD2 extends beyond histone demethylation, impacting DNA methylation, cancer cell reprogramming, E3 ubiquitin ligase activity and DNA damage repair pathways. This study underscores the distinct roles of LSD2, providing insights into their contributions to cancer and other cellular processes.

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Section: Epigenetic Reprogramming Of Cancermentioning

confidence: 99%