Lyophilized hydroalcoholic extract of Passiflora edulis and Zea mays L, as potential arterial hypotension and hypocholesterolemia in hypertensive Mus musculus induced hypertension

Abstract

The leaves of Zea mays L and Passiflora edulis have multipurpose for conventional medicine for their bioactive compounds, however, their use in animal models lacks demonstration and biomedical validation, hence the objective was to evaluate the effect of lyophilized extract of P. edulis Sims and Z. mays L as a potential arterial hypotensive and induce hypocholesterolemia in hypertensive Swiss albino mice. Forty-eight 8-week-old Swiss albino mice were used by dividing into 4 groups: G1-passion fruit ( 50mg [n= 4], 100 mg [n= 4], and 200 mg [n= 4]), G2-purple corn (50 mg [n= 4], 100 mg [n= 4], and 200 mg [n= 4]), and G3-controls: negative control (distilled water [n= 12]), G4-positive control (N-nitro-L-arginine methyl ether (L-NAME) [n= 12]). Mice were fasted to assess systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), glucose and cholesterol at baseline and post induction with L-NAME by indirect method. At 4 weeks of study the animals of G1-passion fruit and G2-purple corn showed significant antihypertensive and hypocholesterolemia effect (p<0.05) resulting the concentration 200 mg as optimal reducer and stabilizer of SBP, DBP, MAP, glucose and cholesterol. In conclusion, the lyophilized extract of P. edulis (passion fruit) and Z. mays L (purple corn) leaves at 200 mg concentration showed excellent antihypertensive and hypocholesterolemia effects in hypertensive Swiss albino mice 2023. Journal of the Selva Andina Animal Science ® . Bolivia. All rights reserved.