Lymphopenia as risk factor for development of severe infections in patients with systemic lupus erythematosus: a case-control study

Abstract

Our data suggest that lymphopenia, PDN treatment and low levels of C3 are independent risk factors for the development of severe infections in SLE patients, including diverse microorganisms, not only opportunistic infections.

Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis

“…A similar mechanism is likely in AH due to the florid inflammation. Lymphopenia has been found to be a risk factor for severe infections in systemic lupus erythematosus (32). CTLs and NK cells have long been known to be important for viral clearance, and there is now evidence for a role also in the clearing of bacterial and fungal infections (3,10,21,24,27).…”

La lymphopénie dans la polyarthrite débutante : impact sur le diagnostic et les résultats à 3ans (la cohorte Espoir)

“…Certaines études donnent un taux de lymphocytes sanguins < 1500/mm 3 [36] et autres < 1000 mm 3 [14][15][16][17][18][19][20]. Nous avons utilisé la valeur seuil la plus basse, qui a été choisie pour la plupart des études précédentes.…”

“…Dans notre étude, la lymphopénie a été définie comme un taux de lymphocytes sanguins circulant < 1000/mm 3 , valeur seuil considérée comme la plus pertinente dans les études précédentes [14][15][16][17][18][19][20].…”

Lymphopenia in early arthritis: Impact on diagnosis and 3-year outcomes (ESPOIR cohort)

“…Some studies used 1500/mm 3 [36] and others 1000/mm 3 [14][15][16][17][18][19][20]. We used the lower of these two cut-offs, which was chosen for most of the previous studies.…”

“…In our study, lymphopenia was defined as a peripheral blood lymphocyte count < 1000/mm 3 , cut-off considered as the most relevant in previous studies [14][15][16][17][18][19][20].…”