Lymphomatoid papulosis followed by Hodgkin's lymphoma. Differential response to therapy

In search of prognostic indicators for lymphomatoid papulosis: A retrospective study of 123 patients

“…The previously reported association of LyP with hematologic malignancies 2,[4][5][6][7][8]22,23 was also confirmed in our study. Of the 123 patients, 17 (14%) had an associated hematologic malignancy.…”

“…that were usually asymptomatic and typically were located on the trunk and extremities, primarily in male patients. [1][2][3][4][5][6][7][8] The mean follow-up time of 4 years (range, 2 months to 14 years) revealed that different treatments did not seem to alter the course of LyP.…”

“…Now, more than 40 years later, we are still unable to identify the 10% to 20% of patients in whom lymphoma will develop, whether it be CD30 1 anaplastic large-cell lymphoma (ALCL), mycosis fungoides (MF), or Hodgkin disease. [2][3][4][5][6][7][8] The current World Health Organization (WHO)eEuropean Organization for Research and Treatment of Cancer (EORTC) classification has listed LyP as a primary, cutaneous, CD30 1 lymphoproliferative disorder. 9,10 Classifying the disorder from a pathologic perspective has yielded 3 histologic types of LyP: type A, type B, and type C. The most common of these is type A, which has large atypical lymphocytes resembling Reed-Sternberg cells of Hodgkin lymphoma with a mixture of inflammatory cells in a wedge-shaped distribution throughout the dermis.…”

Prognosis of Lymphomatoid Papulosis

“…The available therapeutic options for the treatment of LyP are limited. Combination chemotherapy and/or ionizing radiation have been abandoned because of toxicity and because LyP lesions were only temporarily suppressed (whereas lymphoma was responsive) [11]. Similarly, photochemotherapy, topical carmustine, antibiotics, and topical or systemic corticosteroids have only transient effects.…”

Persistent agmination of lymphomatoid papulosis: An equivalent of limited plaque mycosis fungoides type of cutaneous T-cell lymphoma

“…7 LyP can be seen in association with other lymphoproliferative disorders. [8][9][10][11][12][13][14][15][16][17][18] The lymphoma most commonly associated with LyP is MF. The coexistence of MF and LyP in a patient is readily appreciated with the distinct morphologies yet gene studies reveal the same clonal rearrangement of the T-cell receptor gene.…”