Lymphomatoid papulosis: a clinical and histopathologic review and follow-up study of 34 cases in Taiwan

Evaluation of Associated Lymphomas and Their Risk Factors in Patients with Lymphomatoid Papulosis: A Retrospective Single-Center Study from Turkey

“…Almost one-third of the patients (n=20, 32.8%) in the current study had secondary lymphomas including MF (n=19), sALCL (n=2), and pcALCL (n=1) (2 patients had both MF and sALCL). This rate was within the range of the rates previously reported, varying from 6% to 64% [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. However, the frequency of MF in LyP patients (31.1%) was strikingly high in our series with a percentage of 86.4% among all secondary lymphomas, exhibiting one of the highest associations of MF with LyP when compared with formerly reported studies stating rates of 5% to 39% for the patients having this cutaneous T-cell lymphoma in their series [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 15 , 16 , 17 , 18 ].…”

“…Being the largest study conducted in Turkey on LyP patients, this study highlights some similarities as well as some differences from previous reports [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. While many studies on the demographics of LyP, including the largest series reported from the Netherlands [ 6 ], determined a male predominance [ 6 , 7 , 8 , 9 , 10 , 12 , 13 , 14 , 15 ], the present study shows near equality between the sexes with a slight female predominance. The mean age at diagnosis of these 61 LyP patients was 36.4 years, which is a little younger than that reported in previous studies that included adult and pediatric patients [ 6 , 8 , 12 , 13 , 15 , 16 , 17 , 18 ].…”

“…LyP has an almost excellent prognosis with a 10-year survival rate of up to 100%, with a variable clinical course ranging from a few to frequent relapses [ 5 ]. However, this good prognosis may change in patients with associated cutaneous and systemic lymphomas [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Possible risk factors for secondary lymphomas and the frequency of this association remain unclear [ 7 , 9 , 10 , 11 , 15 , 16 , 17 , 18 ].…”

Type D Lymphomatoid Papulosis: An uncommon Variant. A case report and review of the literature

“…Spontaneous regression of LyP is seen almost universally and recurrence in crops establish a chronicity that generally last for years, even though most of patients with LyP remain in good health. No clinical or pathological features can predict increased risk for developing malignancy and although it is not an aggressive malignant process, patients with LyP have an increased risk for developing a nonlymphoid tumour or more commonly a lymphoma (10-20%) including mycosis fungoides, Hodgkin's disease, and cutaneous and systemic CD30+ large-cell lymphoma and 10% of these are associated with extracutaneous involvement [3,9,21,22,[27][28][29][30]. The prognosis of LyP is characterized by disease-specific 5-year survival rates around 100%.…”

“…Treatment should be individualized. It goes from simple observation to the use of drugs when this is required [22]. Cases with few lesions that resolve without scars do not require active treatment [31].…”