Lymphomatoid granulomatosis

Abstract

overall success rate is about 75 percent even under optimal conditions of cell culture and analysis. Physicians must bear in mind that diagnostic amniocentesis should be undertaken with the understanding that abortion is the only available therapy.

Current histological diagnosis of lymphomatoid granulomatosis

“…1 It has weathered redefinition and reclassification, and has maintained itself as a clinicopathological entity, 2 whereas many contemporary lesions such as histiocytic lymphoma, reticulum cell sarcoma, malignant histiocytosis, and many others 3 have fallen by the wayside.…”

“…1,2,[4][5][6] The infiltrating cells show a distinct predilection for vascular invasion and are associated with necrosis, albeit central ('tumor') necrosis in the nodules rather than classic wedge-shaped infarct-like necrosis. There are varying numbers of large transformed lymphocytes, which, at the high-grade end of the spectrum, occur in sheets, which, field for field, are indistinguishable from diffuse large (B) cell lymphoma.…”

“…LYG more frequently affects males and typically presents in the fifth decade; affected patients most frequently show evidence of lung involvement, followed by central nervous system, skin, liver, and kidney. 1,2,5,6 The demographics of LYG still derive primarily from the two largest series, which predate the current definition of LYG. 1,5 Although LYG has persisted in the lexicon of hematopathology and pulmonary pathology, it has not escaped redefinition.…”

Epstein-Barr virus–associated lymphoproliferative disorders

“…The most common site of involvement is the lung, with less frequent involvement of other extranodal sites such as the skin, kidney, liver, and central nervous system (CNS) [55]. Since it was first described in 1972 by Liebow et al [56] and for nearly 2 decades, lymphomatoid granulomatosis was thought to be a T-cell lymphoproliferative disorder because of the predominance of CD4-positive helper T cells and the failure to detect any associated B-cell gene rearrangements [57,58].…”

Pyrexia, Lung nodules, Granulomas: Pulmonary Lymphomatoid Granulomatosis

“…Lymphomatoid granulomatosis (LYG) was first described by Liebow et al as a clinicopathological entity closely mimicking Wegener's granulomatosis [1]. For the next 20 years this clinical entity remained in controversy for its exact etiology.…”