Lymphoma and Targeted Therapies

Smith, Sonali M.; Vose, Julie M.

doi:10.1002/9781118468678.ch17

Cited by 2 publications

(3 citation statements)

References 85 publications

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“…Immunotherapy is when a patient utilizes their own immune system to fight cancer [69]. This treatment therapy boosts and changes how the patient's immune system works to detect, locate, and fight the cancer cells [69,70]. Moreover, targeted therapy can also be used as a treatment for cancer.…”

Section: Current Cancer Treatment Therapiesmentioning

confidence: 99%

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Moringa oleifera: A Review on the Antiproliferative Potential in Breast Cancer Cells

Moremane,

Abrahams,

Tiloke

2023

CIMB

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The global burden of female breast cancer and associated deaths has become a major concern. Many chemotherapeutic agents, such as doxorubicin, have been shown to have adverse side effects. The development of multi-drug resistance is a common occurrence, contributing to chemotherapeutic failure. The resistance of breast cancer cells to drug treatment leads to a decline in the treatment efficacy and an increase in cancer recurrence. Therefore, action is required to produce alternative drug therapies, such as herbal drugs. Herbal drugs have been proven to be beneficial in treating illnesses, including cancer. This review aims to highlight the antiproliferative potential of Moringa oleifera (MO), a medicinal tree native to India and indigenous to Africa, in breast cancer cells. Although MO is not yet considered a commercial chemopreventive drug, previous studies have indicated that it could become a chemotherapeutic agent. The possible antiproliferative potential of MO aqueous leaf extract has been previously proven through its antioxidant potential as well as its ability to induce apoptosis. This review will provide an increased understanding of the effect that MO aqueous leaf extract could potentially have against breast cancer.

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Section: Current Cancer Treatment Therapiesmentioning

confidence: 99%

“…Moreover, targeted therapy can also be used as a treatment for cancer. Targeted therapy can be utilized as monotherapy or combined with other treatments including radiation, chemotherapy, or surgery and can also be used as an adjuvant [70].…”

Section: Current Cancer Treatment Therapiesmentioning

confidence: 99%

Moringa oleifera: A Review on the Antiproliferative Potential in Breast Cancer Cells

Moremane,

Abrahams,

Tiloke

2023

CIMB

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“…have become area of cancer research 3,4,5 . The term 'targeted therapy' confers to a new group of anticancer agents contrived to interfere with a distinguished molecular target (generally a protein or enzyme) that is postulated to have a pivotal role in tumor development.…”

mentioning

confidence: 99%

Untitled

2023

IJPSR

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Cancer is a preminent cause of death worldwide after heart disease. Although there are many types of cancer treatments, depending on the type of cancer and its stages, due to their complexity and adverse cytotoxic effects, some novel targets at the molecular level that are cancer-specific have become the area of research for more than a decade. Some targets have been identified, and CDKs are among them. They play a pivotal role in the cell cycle. This has directed to developing of novel Cyclin-Dependent Kinase Inhibitors with a major emphasis on designing compounds that can effectively inhibit the cell cycle progression in cancer by inhibiting the CDKs selectively, such as abemaciclib. In this study, we have generated and evaluated some CDKIs. These compounds were designed to target CDK6 (PDB ID: 5L2S). The bio-affinity values and binding modes of all designed analogs were evaluated and the pharmacokinetic profile (Caco-permeability, efflux, fdp, vdss, bbb parameters) was also examined. The study exhibited significant findings and analogs 10c, 20a and 34b with docking scores -12.11, -14.91, and -12.41 kcal/mol, respectively, were found to be more potent inhibitors of the CDK6 than abemaciclib (docking score -6.54) and also possess good pharmacokinetic profile. These findings proved them a good candidate for future research. INTRODUCTION:The unconstrained growth of cells characterizes cancer. Different factors may be responsible for cancer e.g., chemical, environmental, mutagenic and viral that leads to an abrasion in the expression of proto-oncogenes, the product of which control normal cell life. The mutation of these genes leads to the formation of oncogenes through a sequential multistep process that results in the development of cancer 1 .

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Lymphoma and Targeted Therapies

Cited by 2 publications

References 85 publications

Moringa oleifera: A Review on the Antiproliferative Potential in Breast Cancer Cells

Moringa oleifera: A Review on the Antiproliferative Potential in Breast Cancer Cells

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