Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case

Singh, Naorem Gopendro; Mannan, Abul Ala Syed Rifat; Rifaat, Amre A.; Kahvic, Mirza

doi:10.4103/0256-4947.57173

Cited by 10 publications

(6 citation statements)

References 14 publications

(34 reference statements)

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“… 4 Histological features of LELC closely resemble nasopharyngeal lymphoepithelioma, with the tumor growing in the nests, sheets, or cords of large undifferentiated malignant epithelial cells in the background of dense inflammatory infiltrate comprising mainly lymphocytes, plasma cells, and a few eosinophils and neutrophils. 1 Amin et al categorized LELC of the urinary bladder into three subgroups based on lymphoepithelioma component: pure (100%), predominant (> 50%), and focal (< 50%). These subgroups significantly determine the prognosis as disease-free survival is higher in pure and predominant LELCB than in mixed type.…”

Section: Discussionmentioning

confidence: 99%

“…Carcinomas with similar histological features arising outside the nasopharynx are known as LELC, which have been reported in various organs such as the thymus, cervix, and salivary glands. 1 Involvement of urinary bladder was first reported by Zukerberg et al in 1991 with a reported incidence between 0.4% and 1.3% of all bladder carcinomas. 2 It has been categorized into three subgroups: pure (100% lymphoepithelioma component), predominant (between 50% and 100%), and focal (< 50%).…”

Section: Introductionmentioning

confidence: 96%

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Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

et al. 2021

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Lymphoepithelioma-like carcinoma of the urinary bladder is a rare variant of urothelial carcinoma that was first described by Zukerberg in 1991 and confirmed as a type of urothelial carcinoma by the WHO classification of the urinary system tumors. A 63-year-old man presented with the chief complaint of gross hematuria for 2 months. Sections from transurethral resection of the bladder revealed urothelial carcinoma. A radical cystoprostatectomy was performed and a final histopathological examination revealed high-grade muscle-invasive urothelial carcinoma, lymphoepithelial variant. The patient has been receiving adjuvant chemotherapy with no recurrence reported to date. This is the third case reported in India to date to the best of our knowledge. Owing to its rare presentation, no definite treatment guidelines have been established for this entity. Various studies from the English literature suggest a conservative approach.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

et al. 2021

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“…They are revealed most of the time by haematuria, generally accompanied with urgency. These tumours have a favorable prognosis with a five-year survival of 59%, achieving 62% in the pure type, compared to transitional cell carcinoma [4]. They respond better to chemotherapy than transitional cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Bladder Lymphoepithelioma-Like Carcinoma: Case Report and Literature Review

Lai-Tiong¹,

Rustam²

2016

J Clin Case Rep

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Urinary lymphoepithelioma-like carcinoma is a rare tumour. These tumours are classified according to lymphoepithelioma component as pure (100%), predominant (≥50%) or focal (<50%). We present here an original case of a 54 year-old man who was diagnosed with a LECL of the urinary bladder. The results of histological examination confirmed a high-grade T2 transitional cell carcinoma with LELC >50%. Neoadjuvant gemcitabine and platinium-based chemotherapy was carried out. The patient received four cycles with a good tolerance. After completed chemotherapy, the patient underwent a radical cystoprostatectomy with lymph nodes dissection and bricker urinary diversion. It's difficult to define the optimal strategy, literature reporting only small series. Nevertheless, the benefits of chemotherapy is certain. The outcome is good in the pure and predominant forms and bad in focal subtypes.

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“…Although rates of metastases range from 10% to 15%, the present tumor was associated with a favorable prognosis and a 5-year survival of 59%, achieving 62% in the pure type [8]. The pure or predominant type responds better to chemotherapy than conventional urothelial carcinoma [5], and this provides a potential to salvage bladder function.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Bladder: A Case Report and Review of the Literature

Mori

Ando

Nomura

et al. 2013

Case Reports in Urology

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Lymphoepithelioma-like carcinoma (LELC) in the bladder is uncommon with a reported incidence of 0.4%–1.3% of all bladder carcinomas. In Japan, some occurrences of LELC have been reported in the renal pelvis and ureter but only two in the bladder. A bladder tumor was identified in a 70-year-old man suffering from macroscopic hematuria for 2 months. Sections of the transurethral tumor resection showed invasive high-grade urothelial carcinoma. The patient was diagnosed with local invasive bladder tumor, and cystectomy with ileal conduit formation was performed. The final pathological evaluation was predominant LELC with urothelial carcinoma. We present a new case of LELC in the bladder and performed a review of all published cases of LELC in the urinary tract to obtain its characteristics and prognostic guide.

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Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case

Cited by 10 publications

References 14 publications

Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

Lymphoepithelioma-Like Carcinoma of Urinary Bladder with Diagnostic Dilemma: Case Report of a Rare Variant of Urothelial Carcinoma

Bladder Lymphoepithelioma-Like Carcinoma: Case Report and Literature Review

Lymphoepithelioma-Like Carcinoma of the Bladder: A Case Report and Review of the Literature

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