Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature

Welch, Preston Q.; Williams, Stephen B.; Foss, Robert D.; Tomaszewski, M.; Gupta, Anish; Ojha, Junu

doi:10.1016/j.tripleo.2010.05.075

Cited by 41 publications

(59 citation statements)

References 35 publications

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“…Lymphoid stroma-rich carcinomas arising in other organs are called LELCs and have been reported in a variety of anatomic sites including the skin [17-20], lacrimal and salivary glands [21,22], thyroid gland [23], thymus [24], breast [25], lung [26], esophagus [27], stomach [28], colon [29], renal pelvis [30-33], ureter [32], kidney [31], bladder [34], prostate [31], uterine cervix [35], vulva [36,37], and vagina [38]. LELC in the liver has also been reported, but most of these cases have instead been referred to as LEL-CCCs [1-8].…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature

et al. 2013

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We report a rare case of lymphoepithelioma-like hepatocellular carcinoma. A 79-year-old Japanese man had undergone curative resection of extrahepatic bile ducts because of bile duct cancer 9 years prior. The bile duct cancer was diagnosed as mucosal adenocarcinoma, and the patient had been followed up every 6 months for the last 9 years. A recent computed tomography examination revealed a tumor, 4.2 cm in size, in the lateral segment of the liver. Based on the imaging findings, the tumor was diagnosed as hepatocellular carcinoma. Serology tests were negative for hepatitis B and C viruses. Chest and abdominal image analyses showed no evidence of metastasis, but a swollen lymph node was noted around the abdominal aorta. The patient subsequently underwent extended lateral segmentectomy and resection of the swollen lymph node. Microscopically, the tumor had the characteristic appearance of poorly differentiated hepatocellular carcinoma. Moreover, an abundant infiltration of inflammatory cells was observed in the tumor. Therefore, we diagnosed the tumor as lymphoepithelioma-like hepatocellular carcinoma. The resected para-aortic lymph node also had a carcinoma with features similar to those of the main tumor. The patient has been alive for 20 months since performance of the surgery. Since the first report of lymphoepithelioma-like hepatocellular carcinoma in 2000, only nine cases have been reported in the medical literature, and the clinicopathological features of the disease have not been well documented. Herein, we describe the clinicopathological features of this case for further understanding of the disease and review past cases in the literature.

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Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature

et al. 2013

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“…Lymphoepithelioma-like carcinoma has been reported in a variety of anatomic sites that include skin [13][14][15][16] , lacrimal and salivary glands 17,18 , thyroid gland 19 , thymus 20 , breast 3 , lung 21 , esophagus 22 , stomach 23 , colon 24 , hepatobiliary system 25,26 , renal pelvis [27][28][29][30] , ureter 28 , kidney 27 , bladder 31 , prostate 27 , uterine cervix 32 , vulva 33,34 , and vagina 35 . The foregoing sites typically have better outcomes than are seen with aggressive nasopharyngeal tumours; however, they do demonstrate the potential for local spread, angioinvasion, and metastasis to lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Breast: A Diagnostic and Therapeutic Challenge

et al. 2012

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also present an overview of our patient's proposed treatment in the context of the 16 other reported lelc cases. CASE PRESENTATIONA 55-year-old postmenopausal woman originally from Ghana presented with a 4-week history of left breast tenderness and an upper outer quadrant mobile breast mass. She had been mammographically screened, with the most recent mammogram (performed 1 year before her presentation) having demonstrated no abnormalities. Her past medical history was unremarkable, with a surgical history of Cesarean section, tubal ligation, and hernia repair. She was gravida 2, para 2, with menopause having occurred at age 53. On systems review, she denied fevers, chills, or night sweats. No weight loss was reported, and she was asymptomatic but for left breast tenderness.Physical examination revealed no cervical or axillary adenopathy, but was significant for a diffusely swollen left breast with a discrete, mobile 4-cm mass. The exam was otherwise noncontributory.Mammography revealed a 3-to 4-cm upper outer quadrant density with spot compression views showing lobulated margins. No evidence of calcifications was noted. Breast ultrasonography showed a 4.3×3.5×2.6-cm lobulated, poorly marginated, hypoechoic solid mass. Computed tomography of the thorax, abdomen, and pelvis showed no evidence of distant metastases and the presence of an 8-cm left breast mass with a uniform low-density component (Figure 1).Fine-needle aspirate yielded a cellular specimen noteworthy for single and groups of abnormal elongated cells with visible nucleoli presenting together with lymphocytes and plasma cells. A bone marrow biopsy revealed normocellular marrow with no evidence of lymphoproliferative disorder.An excisional biopsy was followed by 3 successive pathology reviews. The initial consultant ABSTRACTWe present a patient with lymphoepithelioma-like carcinoma (lelc) of the breast whose diagnosis is illustrative of the pathology nuances that must be taken into account to successfully reach correct identification of the disease. We also present an overview of our patient's proposed treatment in the context of 16 other reported lelc cases. Although lelc cases are rare, a sufficient number have been reported to discern the natural history of this pathologic entity and to undertake a review of those cases and of the application of oncologic first principles in their management. Given the potential for locoregional spread and distant metastases in lelc, adjuvant therapy has a role in the treatment of this entity.

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“…NPCs, major salivary gland-associated LECs, and LEC of the head and neck skin have been reviewed recently [36][37][38]. These are relatively distinct diseases distinguished by the clinical course and treatment outcome.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelial Carcinoma: Two Case Reports and a Systematic Review of Oral and Sinonasal Cases

Rytkönen

Hirvikoski

Salo

2011

Head and Neck Pathol

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Lymphoepithelial carcinoma (LEC) is a rare malignancy. Histologically, it is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. Herein, we report two cases of LEC in the head and neck region that presented to Oulu University Hospital. Our first case is a 30-year-old man with LEC in the left maxillary sinus. The second case is a 49-year-old man with LEC in the soft palate and uvula with regional lymph node metastases at diagnosis. In addition, a systematic review of the literature from 1980 to 2010 was performed with MEDLINE and cross-references were searched manually. Case reports and clinical series of oral, oropharyngeal, nasal, and paranasal sinus LECs were reviewed revealing a total of 110 cases. Most of the oral cases were found in the tonsils (n = 29), oropharynx (n = 19), and in oral mucosa (n = 18), while sinonasal cases (n = 40) were mainly in the paranasal sinuses and nasal cavity. From 37 case reports, including ours, the median age was 58 and 62 years for sinonasal and oral/oropharyngeal LECs, respectively. Oral and oropharyngeal LECs have a 70.0% tendency to metastasize and 16.6% spread locally. In contrast, none of the nasal and paranasal LECs metastasized, but 60% spread locally. Epstein-Barr virus (EBV) had been detected in 87.5% of all tested LEC cases. Treatment of LECs, during the last decade, has largely consisted of surgery, combined with radiotherapy or chemoradiation. Although local spread or nodal metastases are fairly common at the time of diagnosis, the mortality rate of adequately treated LEC patients is low.

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Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature

Cited by 41 publications

References 35 publications

Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature

Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature

Lymphoepithelioma-Like Carcinoma of the Breast: A Diagnostic and Therapeutic Challenge

Lymphoepithelial Carcinoma: Two Case Reports and a Systematic Review of Oral and Sinonasal Cases

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