Lymphoepithelial Carcinoma of Salivary Glands

Lymphoepithelial carcinoma of the parotid gland: Clinicopathological analysis of 146 cases from a single institute

“…Patients with salivary gland LEC have a wide age range, from 10 to 86 years old, with an average age of 47 years and a median of 46.0 years. 4 In the present study, the ages of the patients ranged from 15 to 77 years old, with a mean age of 43.9 years and a median age of 43.0 years. This is similar to the demographic data for endemic areas, but younger than the ages of patients in nonendemic regions (mean, 55.4 years; median, 55.0 years).…”

“…This is similar to the demographic data for endemic areas, but younger than the ages of patients in nonendemic regions (mean, 55.4 years; median, 55.0 years). 2,4 In Zhan et al's review of 220 cases of parotid LEC in America, 107 (48.6%) patients were older than 62 years old. 2 In the present series, parotid LEC was more common among younger persons than in older persons, with the fourth decade being the peak incidence for all the patients and the female patients.…”

“…8 However, in a review of salivary LEC cases, the author aggregated all reported cases and did not observe any sex predilection in the distribution of the cases. 4 The clinical presentation of parotid LEC usually is nonspecific. 4,25 Its characteristic feature is parotid swelling or growth of a mass over a broad time frame.…”

“…4 The clinical presentation of parotid LEC usually is nonspecific. 4,25 Its characteristic feature is parotid swelling or growth of a mass over a broad time frame. In the present study, the disease duration after first detection of a mass ranged from 1 week to 20 years.…”

“…Tenderness and facial paresis are unusual symptoms experienced by patients with salivary gland LEC. 3,4 Obvious cervical lymphadenopathy is detected clinically or radiographically in about 17.0%-45.1% of patients with salivary gland LEC 2,4,11,12 (40.5%-43.4% in Chinese patients). 11,12 Our data indicated that at the time of diagnosis, regional lymph nodes metastasis was observed in 32.2% of patients with parotid LEC, often with bulky nodal disease (69.5% of all node-positive cases were N2).…”