Lymphocytotoxicity in recurrent aphthous stomatitis. Lymphocytotoxicity for oral epithelial cells in recurrent aphthous stomatitis and Bechet syndrome

Rogers, R. S.

doi:10.1001/archderm.109.3.361

Cited by 47 publications

(25 citation statements)

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“…We and others have found abnormalities in patients with BD similar to those observed in certain autoimmune disorders [3][4][5][6][7][8][9][10][11]; these include induction of lymphocyte transformation by oral mucosa, cytotoxic effect of lymphocytes on oral mucosa, DTH skin reaction to skin homogenates, histologic features characterized by an early intense lymphocytic infiltration in oral aphthous ulceration, suppressor T cell dysfunction, defective IL-2 production of mitogen-activated T cells, and the presence of in vivo activated B cells.…”

Section: Introductionsupporting

confidence: 67%

Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behçet's disease (BD) in Japan

Kaneko

Suzuki

Yamashita

et al. 1997

Clinical and Experimental Immunology

119

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SUMMARYBD is prevalent in the area of the Silk Route. It has been shown that hsp are involved in the T cell activation in patients with BD in the UK, where this disease has developed sporadically. We have thus examined whether the T cell response to the hsp-derived peptides may be induced in patients with BD in Japan, an east pole of the Silk Route. As with patients in the UK, the human 60-kD hsp peptide 336-351 also yielded vigorous proliferation of T cells in Japanese patients with BD, but neither in normal subjects nor in patients with rheumatoid arthritis (RA); there was significant association between proliferation by this peptide and the presence of ocular lesion, but not any other symptoms of BD. To clarify whether the peptide stimulates T cells as a polyclonal activator, a specific antigen or a superantigen-like substance, we analysed T cell receptor (TCR) usage of responding T cells by means of MoAbs specific for TCR Vb subfamily and polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP)-based technique. We found that T cells with certain TCR Vb subfamilies (including Vb5.2-3, 8, 13.6, 18, 21.3) were increased in circulation and responded to the hsp peptide in an antigen-specific fashion. In addition, TCR Vb gene-amplified products of freshly isolated T cells of patients with BD formed several bands in the PCR-SSCP analysis; some of them became prominent after stimulation with the peptide. This suggests that T cells in patients with this disease have already been expanded oligoclonally in vivo, which may be a result of stimulation by triggering antigens, including the hsp peptide. In addition, hsp peptide stimulation induced proinflammatory cytokine mRNA expression in peripheral blood mononuclear cells, including IL-8, tumour necrosis factor-alpha (TNF-a) and TNF-b in eight out of eight patients studied. Taken together, the results suggest that hsp antigen may play a role in the pathogenesis of BD, not only in the area of the Silk Route, but also outside the Silk Route area.

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Section: Introductionsupporting

confidence: 67%

Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behçet's disease (BD) in Japan

Kaneko

Suzuki

Yamashita

et al. 1997

Clinical and Experimental Immunology

119

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“…The hypothesis of a cell-mediated mechanism in the pathogenesis of Behget's disease is mainly based on the following features demonstrated in the process: induction of lymphocyte transformation to oral mucosa [1,2]; cytotoxic effect of lymphocytes to oral mucosa [3,12]; delayed hyper sensitivity type of skin reaction [4,13], and histological features characterized by an early intense lymphocytic infiltration [14]. To these features we may add the normal transformation of T lymphocytes in response to mitogens in comparison with controls inspite of their decreased number as revealed in a previous study conducted in our department [5].…”

Section: Discussionmentioning

confidence: 99%

Leucocyte Migration Inhibition in Behçet’s Disease

Haim¹,

Gilhar²,

Mekori³

et al. 1979

Dermatology

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The leucocyte migration inhibition (LIF) was investigated in 16 patients with Behçet’s disease, 5 while in the active stage of the process, 3 both during relapse and remission, and 8 during remission of symptoms. In all patients skin tests with various antigens and with a needle prick and physiological saline were simultaneously performed. The results indicate a strong correlation between the activity of the disease, skin reactivity and the reactivity of LIF.

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“…This hypothesis was mainly based on the following features demonstrated in the process: induction of lympho cyte transformation by oral mucosa [6]; cytotoxic effect of lymphocyte to oral mucosa [7,8]; delayed hypersensitivity type of skin reaction to skin homogenates [9,10], and the histological features characterized by an early intense lymphocytic infiltration [11,12].…”

Section: Discussionmentioning

confidence: 99%

Aspects of Lymphocyte Function in Behçet’s Disease

et al. 1976

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Aspects of lymphocyte function were investigated, in vitro, in nine patients with active Behçet’s disease. The rosette formation technique revealed a slight decrease in number of T lymphocytes and more so of B lymphocytes. In spite of their low number, the transformation of the T lymphocytes in response to mitogens did not show a significant difference from that of normal controls. This may indicate a hyperreactivity, and in two instances a spontaneous blastogenesis prior to addition of mitogens, was also noted. The immunoglobulins and complement levels in serum were within normal limits.

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Lymphocytotoxicity in recurrent aphthous stomatitis. Lymphocytotoxicity for oral epithelial cells in recurrent aphthous stomatitis and Bechet syndrome

Cited by 47 publications

References 0 publications

Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behçet's disease (BD) in Japan

Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behçet's disease (BD) in Japan

Leucocyte Migration Inhibition in Behçet’s Disease

Aspects of Lymphocyte Function in Behçet’s Disease

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