Lymphocytic Choriomeningitis Virus in Employees and Mice at Multipremises Feeder-Rodent Operation, United States, 2012

Knust, Barbara; Ströher, Ute; Edison, Laura; Albariño, César G.; Lovejoy, Jodi; Armeanu, Emilian; House, Jennifer; Cory, Denise; Horton, Clayton; Fowler, Kathy L.; Austin, Jessica D.; Poe, John; Humbaugh, Kraig; Guerrero, Lisa Wiggleton; Campbell, Shelley; Gibbons, Aridth; Reed, Zachary; Cannon, Deborah; Manning, Craig; Petersen, Brett W.; Metcalf, D. J.; Marsh, Bret; Nichol, Stuart T.; Rollin, Pierre E.

doi:10.3201/eid2002.130860

Cited by 48 publications

(38 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although virus was never detected in healthy individuals and all patients with confirmed Wēnzhōu virus infections experienced similar symptoms of acute febrile bronchitis, the non-detection of co-infecting agents in three cases despite extensive testing does not mean that other untested or unknown pathogens were not present. However the clinical picture observed was similar to that reported for milder LCMV infection ( Baum et al, 1966 ; Knust et al, 2014 ). If like LCMV, Wēnzhōu virus rarely causes distinctive severe disease, then despite the high apparent incidence of the infection indicated by the retrospective serological study, causality is unlikely to be confirmed without further surveys.…”

Section: Discussionsupporting

confidence: 86%

Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia

Blasdell

Duong

Éloit

et al. 2016

eLife

View full text Add to dashboard Cite

Southeastern Asia is a recognised hotspot for emerging infectious diseases, many of which have an animal origin. Mammarenavirus infections contribute significantly to the human disease burden in both Africa and the Americas, but little data exists for Asia. To date only two mammarenaviruses, the widely spread lymphocytic choriomeningitis virus and the recently described Wēnzhōu virus have been identified in this region, but the zoonotic impact in Asia remains unknown. Here we report the presence of a novel mammarenavirus and of a genetic variant of the Wēnzhōu virus and provide evidence of mammarenavirus-associated human infection in Asia. The association of these viruses with widely distributed mammals of diverse species, commonly found in human dwellings and in peridomestic habitats, illustrates the potential for widespread zoonotic transmission and adds to the known aetiologies of infectious diseases for this region.DOI: http://dx.doi.org/10.7554/eLife.13135.001

show abstract

Section: Discussionsupporting

confidence: 86%

Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia

Blasdell

Duong

Éloit

et al. 2016

eLife

View full text Add to dashboard Cite

show abstract

“…In the absence of barriers to superinfection, an incalculable number of novel viral genotype configurations, made even more numerous by frequent intra-segment recombination and an error-prone polymerase, could rapidly evolve and accumulate within individual animals and in breeding facilities. In theory, this situation could be exacerbated by the introduction of mammalian arenavirus-infected rodents as feedstock [66], although it is unknown whether recombinant or reassortant mammalian/reptile arenaviruses are possible or viable. Regardless, further investigation of high-density reptile breeding and feed rodent facilities should be considered.…”

Section: Discussionmentioning

confidence: 99%

Widespread Recombination, Reassortment, and Transmission of Unbalanced Compound Viral Genotypes in Natural Arenavirus Infections

et al. 2015

View full text Add to dashboard Cite

Arenaviruses are one of the largest families of human hemorrhagic fever viruses and are known to infect both mammals and snakes. Arenaviruses package a large (L) and small (S) genome segment in their virions. For segmented RNA viruses like these, novel genotypes can be generated through mutation, recombination, and reassortment. Although it is believed that an ancient recombination event led to the emergence of a new lineage of mammalian arenaviruses, neither recombination nor reassortment has been definitively documented in natural arenavirus infections. Here, we used metagenomic sequencing to survey the viral diversity present in captive arenavirus-infected snakes. From 48 infected animals, we determined the complete or near complete sequence of 210 genome segments that grouped into 23 L and 11 S genotypes. The majority of snakes were multiply infected, with up to 4 distinct S and 11 distinct L segment genotypes in individual animals. This S/L imbalance was typical: in all cases intrahost L segment genotypes outnumbered S genotypes, and a particular S segment genotype dominated in individual animals and at a population level. We corroborated sequencing results by qRT-PCR and virus isolation, and isolates replicated as ensembles in culture. Numerous instances of recombination and reassortment were detected, including recombinant segments with unusual organizations featuring 2 intergenic regions and superfluous content, which were capable of stable replication and transmission despite their atypical structures. Overall, this represents intrahost diversity of an extent and form that goes well beyond what has been observed for arenaviruses or for viruses in general. This diversity can be plausibly attributed to the captive intermingling of sub-clinically infected wild-caught snakes. Thus, beyond providing a unique opportunity to study arenavirus evolution and adaptation, these findings allow the investigation of unintended anthropogenic impacts on viral ecology, diversity, and disease potential.

show abstract

“…The disease burden in humans is unknown; an estimated 5% of U.S. house mice carry LCMV (4). Human infection occurs by inhalation of aerosolized urine and droppings of infected rodents (5). The virus is a fetal teratogen, and transplacental vertical transmission with severe effects on infants has been described (6); infection after solid organ transplant (7-9) also have been reported.…”

mentioning

confidence: 99%

Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation — Minnesota, 2015

Talley¹,

Holzbauer²,

Smith³

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

View full text Add to dashboard Cite

Lymphocytic Choriomeningitis Virus in Employees and Mice at Multipremises Feeder-Rodent Operation, United States, 2012

Abstract: Outbreaks can be prevented with strict biosecurity and microbiological monitoring.

Cited by 48 publications

References 25 publications

Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia

Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia

Widespread Recombination, Reassortment, and Transmission of Unbalanced Compound Viral Genotypes in Natural Arenavirus Infections

Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation — Minnesota, 2015

Contact Info

Product

Resources

About