Lymphocytes in Atherosclerosis

Hedrick, Catherine C.

doi:10.1161/atvbaha.114.305144

Cited by 73 publications

(51 citation statements)

References 83 publications

(57 reference statements)

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“…Their ability to secrete proatherogenic cytokines certainly inhibits the atheroprotective action of other subsets . Th2 and Th17 cell populations are also found but their functions are still unclear . The functions of Treg cells in atherosclerosis have been largely investigated and show an overall atheroprotective role .…”

Section: T Cells In Atherosclerosismentioning

confidence: 99%

Follicular regulatory T cell in atherosclerosis

Baptista

Mach

Brandt

2018

Journal of Leukocyte Biology

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Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several aspects remain to be clarified. In the present review, we give a brief overview of the functions of follicular regulatory T cell (Tfr) on follicular T (Tfh) and B cell regulation related to atherosclerosis pathogenesis, including their influence on lymphangiogenesis and lipoprotein metabolism. We will also discuss their potential therapeutics properties in the resolution of established atherosclerotic lesions.

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Section: T Cells In Atherosclerosismentioning

confidence: 99%

Follicular regulatory T cell in atherosclerosis

Baptista

Mach

Brandt

2018

Journal of Leukocyte Biology

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“…83 Of the circulating leukocytes, cells of the myeloid compartment, namely monocytes and neutrophils, are the most highly associated ones with cardiac events. 84, 85, 86, 87 However, an important relationship between adaptive immune cells and CVD has emerged over the past decade (see reviews Hedrick 88 , Wigren et al 89 and Ammirati et al 90 ).…”

Section: Cvd Risk and Inflammation: Focus On Enhanced Hematopoiesismentioning

confidence: 99%

Is the risk of cardiovascular disease altered with anti‐inflammatory therapies? Insights from rheumatoid arthritis

et al. 2016

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Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. Atherosclerosis is the most common form of CVD, which is complex and multifactorial with an elevated risk observed in people with either metabolic or inflammatory diseases. Accumulating evidence now links obesity with a state of chronic low-grade inflammation and has renewed our understanding of this condition and its associated comorbidities. An emerging theme linking disease states with atherosclerosis is the increased production of myeloid cells, which can initiate and exacerbate atherogenesis. Although anti-inflammatory drug treatments exist and have been successfully used to treat inflammatory conditions such as rheumatoid arthritis (RA), a commonly observed side effect is dyslipidemia, inadvertently, a major risk factor for the development of atherosclerosis. The mechanisms leading to dyslipidemia associated with anti-inflammatory drug use and whether CVD risk is actually increased by this dyslipidemia are of great therapeutic importance and currently remain poorly understood. Here we review recent data providing links between inflammation, hematopoiesis, dyslipidemia and CVD risk in the context of anti-inflammatory drug use.

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“…Inflammatory cells accumulate in the adventitia of the abdominal aorta of people who develop aneurysms. T-and B-cells, macrophages, mast cells, dendritic cells, and neutrophils are important for the inflammatory response (11,12). T-cells have been implicated in aortic aneurysm progression by enhancing macrophage-derived matrix metalloproteinase production and vascular smooth muscle cell apoptosis (12).…”

Section: Discussionmentioning

confidence: 99%

“…CD4+ T-lymphocytes have been shown to accelerate atherosclerosis, and Th1 cells -the CD4+ T-effector cells that produce interferon-γ -are found in atherosclerotic plaques. Th17 cells produce interleukin (IL)-17A and IL-17F cytokines and have also been reported to be present in atherosclerotic lesions (11). B-cells have been reported in the adventitia of abdominal aortic aneurysms and have been implicated in their formation through the production of immunoglobulins and cytokines and by regulation of complement activation and T-cells (12).…”

Section: Discussionmentioning

confidence: 99%

Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature

et al. 2017

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133Cardiovascular manifestations in patients with systemic lupus erythematosus (SLE) are common, but aortic aneurysm formation is rare. We present a 63-year-old male SLE patient with a two-year history of skin lesions, leucopenia, pericarditis, mitral valve vegetations consistent with Liebman-Sacks endocarditis, and an aneurysm of the ascending aorta, which was successfully repaired surgically. Histologic examination of the aneurysm showed medial cystic degeneration, smooth muscle necrosis, and mild adventitial perivascular lymphocytic aggregates. This histology is typical of thoracic aneurysms that carry a high risk for aortic dissection and patient death. The case highlights the importance of early detection and treatment of thoracic aortic aneurysms in patients with SLE.

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Lymphocytes in Atherosclerosis

Cited by 73 publications

References 83 publications

Follicular regulatory T cell in atherosclerosis

Follicular regulatory T cell in atherosclerosis

Is the risk of cardiovascular disease altered with anti‐inflammatory therapies? Insights from rheumatoid arthritis

Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature

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