Lymphocyte-to-C-Reactive Protein Ratio Is the Most Sensitive Inflammation-Based Prognostic Score in Patients With Unresectable Metastatic Colorectal Cancer

Abstract

Supplemental Digital Content is available in the text.

Peking Prognostic Score, Based on Preoperative Sarcopenia Status, Is a Novel Prognostic Factor in Patients With Gastric Cancer

“…Okugawa et al recently reported that LCR was the marker to predict the prognosis of CRC and GC cases ( 14 ). Two recent studies found that LCR showed was the most accurate in predicting patient prognosis relative to those existing inflammatory scores like NLR, LMR, PLR, and CAR ( 14 , 33 ).…”

Prognostic Role of Lymphocyte-C-Reactive Protein Ratio in Colorectal Cancer: A Systematic Review and Meta Analysis

“…Lymphocytes inhibit tumor cell proliferation and metastasis by promoting an immune response to the tumor and high CRP levels reflect proliferation and metastasis of tumor cells in patients with advanced cancer, with interleukin levels that can lead to cachexia and malnutrition, resulting in slower clearance of anticancer drugs and increased toxicity associated with therapy (36). On the other hand, relevant studies following the 2019 COVID-19 outbreak suggest that the LCR is potentially a predictive marker for COVID-19 infection and clinical deterioration, and given this evidence, the LCR may also reflect a frail or compromised host state (37)(38)(39)(40).Therefore, increasing LCR may be an effective strategy to improve tumor prognosis in patients with unresectable metastatic colorectal cancer (26).…”

“…Okugawa (20) et al showed that two peripheral blood parameters, lymphocyte count and C-reactive protein level, had the highest correlation with recurrence compared to other parameters, and low preoperative LCR was significantly associated with undifferentiated histology, advanced T-stage, lymph node metastasis, distant metastasis, and advanced grade; reduced preoperative LCR was an independent prognostic factor for disease-free and overall survival, and was an independent risk factor for postoperative complications and surgical site infections in colorectal cancer patients; Wenting Ou (25) et al showed that LCR had the highest prognostic predictive value of all inflammatory scores and that low LCR was significantly associated with multiple clinicopathological features of tumor infiltration and progression. Nakamura (26) et al showed in a study of patients with unresectable metastatic colorectal cancer that the lymphocyte-c-reactive protein ratio was the most sensitive predictor of sustained survival among all prognostic scores based on inflammation.…”

“…showed that LCR had the highest prognostic predictive value of all inflammatory scores and that low LCR was significantly associated with multiple clinicopathological features of tumor infiltration and progression. Nakamura ( 26 ) et al. showed in a study of patients with unresectable metastatic colorectal cancer that the lymphocyte-c-reactive protein ratio was the most sensitive predictor of sustained survival among all prognostic scores based on inflammation.…”

“…Since tumor patients have both inflammatory infections and immune disorders after surgery, and CRP and lymphocyte levels precisely also reflect well the inflammatory infections and immune status of patients after surgery, a series of studies on colorectal cancer patients in recent years have defined the ratio of lymphocytes to CRP as a new index and reported the correlation between LCR and prognosis of colorectal cancer (20)(21)(22)(23)(24)(25)(26)(27)(28)(29). However, the findings of the studies are not uniform and the cut-off values for this index are not consistent; therefore, this study used Meta-analysis to objectively and systematically investigate the prognostic significance of treatment LCR levels in colorectal cancer patients and the relationship between LCR and the clinicopathological characteristics of colorectal cancer patients.…”