Lymphocyte subset numbers depend on the bacterial origin of sepsis

Abstract

Our results indicate that Gram-positive sepsis causes stronger suppression of peripheral blood lymphocyte subsets in comparison to sepsis due to Gram-negative pathogens.

Cellular and Molecular Markers of Outcome in Septic Shock

“…Therefore, a role for T lymphocytes in severe systemic bacterial infections has been described in several studies, and the findings of other investigations have supported the notion that T lymphocytes are involved in the pathogenesis of septic shock (Holub et al 2000;Holub et al 2003;Kabisch et al 1990;Lin et al 1993;Nishijima et al 1986). The NK compartment is characterized as CD3 -CD56 + cells that can be cytotoxic (CD16 + Bright) or produce high amount of cytokines such as IFNγ (CD16 + Dim) (Romagnani et al 2007).…”

“…The role of the lymphocytes in the septic shock it's not clear and it has been studied extensively in the last decades (Holub et al 2000;Holub et al 2003;Lin et al 1993;Menges et al 1999;Nishijima et al 1986). However, there are not many authors that have proposed to use lymphocytes as biomarkers for the outcome of these patients (Keane et al 1983;Monserrat et al 2009a).…”

Absolute counts of peripheral blood leukocyte subpopulations in intraabdominal sepsis and pneumonia-derived sepsis: a pilot study

“…Nevertheless, the site of origin may be important, as suggested by a few papers revealing differences in the immune response during Gram + and Gram -sepsis. The study by Holub et al [4] showed that Gram + sepsis caused a higher decrease in CD4 + , CD8 + , NK cells and total T-lymphocytes than Gram -sepsis. The pattern of immune recovery in Gram + sepsis was different and slower than in Gram -infections [4].…”

“…The study by Holub et al [4] showed that Gram + sepsis caused a higher decrease in CD4 + , CD8 + , NK cells and total T-lymphocytes than Gram -sepsis. The pattern of immune recovery in Gram + sepsis was different and slower than in Gram -infections [4]. Gram positive sepsis is often related to higher mortality than Gram negative sepsis [12] and PDS is mostly of G + etiology, as in our observations.…”

“…Most research papers do not distinguish sepsis according to the site of the primary infection. Some studies have compared the immune response to Gram positive and Gram negative pathogens, which may also be related to the infection site [4]. In this study, we have compared selected components of the cellular immune response in sepsis of pneumonia and peritonitis origin during the later phase of the sepsis (4-6 days).…”