Lymphocyte subpopulations in the skin of patients with chronic urticaria

Mekori, Yoseph A.; Giorno, Ralph; Anderson, Patricia S.; Köhler, Peter F.

doi:10.1016/0091-6749(83)90629-2

Cited by 64 publications

(22 citation statements)

References 22 publications

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“…We did not compare serum-induced wheals with spontaneous wheals because it would have been difficult to biopsy spontaneous wheals of known comparable duration, and, unlike the physical urticarias, chronic urticaria wheals cannot be induced by a more physiological stimulus. Although in earlier histological studies of chronic urticaria attention was focused on mononuclear cell infiltrates [17], Peters and Winkelmann [18] found neutrophil perivascular infiltrates in 10 of 241 urticaria biopsies, and in a later series Winkelmann and Reizner[l9] found that 15.8% of the cases of urticaria had a major neutrophil com ponent in the inflammation. The predominance of neutrophils in early chronic urticaria serum skin test biopsies suggests that pattern and intensity of inflam mation in spontaneous wheals may depend on the timing of biopsy.…”

Section: Discussionmentioning

confidence: 99%

The Pathology of the Autologous Serum Skin Test Response in Chronic Urticaria Resembles IgE-Mediated Late-Phase Reactions

Grattan

Boon

Eady

et al. 1990

Int Arch Allergy Immunol

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The wheal-and-flare response to intradermal autologous serum in chronic urticaria offers a model for study of the pathogenesis of the disorder. Serial biopsies of autologous serum induced wheals were performed in 5 chronic urticaria patients to assess the evolution of the cellular inflammatory response and to look for evidence of mast cell degranulation. Perivascular neutrophils and eosinophils were seen as early as 30 min, becoming more intense and diffuse over 2 h. T lymphocyte numbers were increased by 2 h, CD4⁺ cells outnumbering CD8⁺ cells at 24 h. By 48 h, the neutrophils were clearing, but eosinophils and lymphocytes persisted. The histology of compound 48/80-induced wheals was similar to serum-induced wheals, but there was little or no response to physiological saline (0.16 M). Stainable mast cells were reduced in compound 48/80- and serum-induced wheals when compared to saline skin tests. Mast cell granules appeared swollen and had lost their characteristic lamellar substructure on electron microscopy of a serum-induced wheal biopsied at 10 min. Eosinophil degranulation was also observed at 2 h. The resemblance of the inflammation to the late phase of IgE-mediated immediate hypersensitivity reactions in atopies supports the concept that a circulating factor causes mast cell degranulation in chronic urticaria and may be important in the pathogenesis of the disorder.

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Section: Discussionmentioning

confidence: 99%

The Pathology of the Autologous Serum Skin Test Response in Chronic Urticaria Resembles IgE-Mediated Late-Phase Reactions

Grattan

Boon

Eady

et al. 1990

Int Arch Allergy Immunol

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“…21,22 Other cells may also be found, including mast cells, eosinophils, and neutrophils. A marked increase in lesional mast cell levels was demonstrated in early re¬ ports,22,23 but 2 more recent studies failed to confirm this finding.24,25 There is evidence of eosinophil degranulation in CIU, and extracellular major basic protein was demonstrated in almost 50% of biopsy specimens in 1 report.26 In rare cases, there is a neutrophil infiltrate, thought either to represent a distinct subtype of urti¬ caria or to occur at an early stage of wheal forma¬ tion.2729 fn CfU, however, histopathological studies are hampered by difficulty in knowing the exact duration of wheals, since they cannot be reproducibly induced by any known stimulus.…”

Section: Histopathological Featuresmentioning

confidence: 99%

The Pathogenesis of Chronic Idiopathic Urticaria

Sabroe

Greaves²

1997

Arch Dermatol

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“…Hence, urticaria swellings are characterized by a perivascular infiltrate in the absence of vascular damage, nuclear debris or red cell extravasation [14, 15]. The predominant cell type found in the lesions is the activated T helper lymphocyte that expresses HLA-DR antigen; these cells are arranged perivascularly.…”

Section: Introductionmentioning

confidence: 99%

Immune Profiles of Patients with Chronic Idiopathic Urticaria

Piconi¹,

Trabattoni

Iemoli³

et al. 2002

Int Arch Allergy Immunol

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Background: The immunologic characterization of chronic idiopathic urticaria (CIU) is still incomplete. In particular, it is not known if positivity to the intradermal autologous serum skin test (ASST) identifies an immunologic subset of CIU patients. Methods: Nineteen CIU patients and 15 healthy controls were enrolled in the study. A diagnostic flowchart was designed to select CIU patients, who were then analyzed by ASST. Cytokine and chemokine production and the expression of adhesion molecules was measured in patients and controls. Results: In CIU patients compared to controls, it was found that (1) TNF-α, IL-10, MIP-1α and RANTES production was augmented and IL-2 and INF-γ reduced, and (2) CD44, CD11a and CD62L expression on CD4 and CD8 cells was augmented. Additionally, TNF-α and chemokine production was significantly increased in CIU patients with a negative ASST (p–; n = 10) compared to patients with a positive response to the test. Conclusions: The presence of an inflammatory process in CIU patients is suggested by the findings that the production of both TNF-α and chemokines as well as the expression of adhesion molecules is increased in these patients. Similarly to what is seen in rheumatoid arthritis, augmented IL-10 production might be secondary to the attempt to hamper the inflammatory milieu. Immune profiles are particularly altered in CIU p– patients, in whom a more aggressive therapeutic strategy might be considered.

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Lymphocyte subpopulations in the skin of patients with chronic urticaria

Cited by 64 publications

References 22 publications

The Pathology of the Autologous Serum Skin Test Response in Chronic Urticaria Resembles IgE-Mediated Late-Phase Reactions

The Pathology of the Autologous Serum Skin Test Response in Chronic Urticaria Resembles IgE-Mediated Late-Phase Reactions

The Pathogenesis of Chronic Idiopathic Urticaria

Immune Profiles of Patients with Chronic Idiopathic Urticaria

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