Lymphocyte subpopulations in peripheral blood and malignant effusions of cancer patients

Prognostic role of immune microenvironment in pleural metastases from breast and lung adenocarcinomas

“…These studies mainly focused on T cells, many of them on the subset of T regulatory cells, with only rare reports for other cell types. Two studies (5,6) evaluating the counts of CD4 + and CD8 + cells, the first (5) in 9 pleural and 10 peritoneal metastatic effusions, the second (6) in 6 mesotheliomas, 9 lung carcinomas and 7 tuberculosis pleural, showed higher CD4 + cells counts and unchanged CD8 + counts for all these diseases compared to peripheral blood (5,6), while no differences were seen between the three disease groups (6). Interestingly, in two studies, one (7) with metastatic pleural effusions from variable primaries, and another from lung ADCs (8), T cells were mostly naive or of central memory, and not of effector type, thus suggesting a milieu of immune system escape in this tumor compartment.…”

Prognostic role of immune microenvironment in pleural metastases from breast and lung adenocarcinomas

“…These studies mainly focused on T cells, many of them on the subset of T regulatory cells, with only rare reports for other cell types. Two studies (5,6) evaluating the counts of CD4 + and CD8 + cells, the first (5) in 9 pleural and 10 peritoneal metastatic effusions, the second (6) in 6 mesotheliomas, 9 lung carcinomas and 7 tuberculosis pleural, showed higher CD4 + cells counts and unchanged CD8 + counts for all these diseases compared to peripheral blood (5,6), while no differences were seen between the three disease groups (6). Interestingly, in two studies, one (7) with metastatic pleural effusions from variable primaries, and another from lung ADCs (8), T cells were mostly naive or of central memory, and not of effector type, thus suggesting a milieu of immune system escape in this tumor compartment.…”

Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Etiology

“…In patients with malignant effusions, we noticed increase of the values of CD3, CD4, CD8 and CD16 positive T cells in the pleural malignant fluid versus blood, but these changes were not significant due to different etiologies of malignancy. Some authors demonstrate increased CD4+ T lymphocyte subset in malignant pleural effusion [ 16 , 17 ]. In the literature there are similar findings with explanation that it is due to suppresser activity of lymphocytes in peripheral blood, but also to the immunological reactivity of the pleural effusions [ 18 ].…”

Neopterin, Soluble lnterleukin-2 Receptor and Adenosine Deaminase Levels in Pleural Effusions

“…The highly elevated pleural fluid slL-2R values in TB and malignant pleurisy seems to be due to a high percentage o f activated lymphocytes in these effu sions [19][20][21]. It may reflect the activation o f local im mune status.…”

Prognostic role of immune microenvironment in pleural metastases from breast and lung adenocarcinomas

“…These studies mainly focused on T cells, many of them on the subset of T regulatory cells, with only rare reports for other cell types. Two studies (5,6) evaluating the counts of CD4 + and CD8 + cells, the first (5) in 9 pleural and 10 peritoneal metastatic effusions, the second (6) in 6 mesotheliomas, 9 lung carcinomas and 7 tuberculosis pleural, showed higher CD4 + cells counts and unchanged CD8 + counts for all these diseases compared to peripheral blood (5,6), while no differences were seen between the three disease groups (6). Interestingly, in two studies, one (7) with metastatic pleural effusions from variable primaries, and another from lung ADCs (8), T cells were mostly naive or of central memory, and not of effector type, thus suggesting a milieu of immune system escape in this tumor compartment.…”

Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Etiology

“…In patients with malignant effusions, we noticed increase of the values of CD3, CD4, CD8 and CD16 positive T cells in the pleural malignant fluid versus blood, but these changes were not significant due to different etiologies of malignancy. Some authors demonstrate increased CD4+ T lymphocyte subset in malignant pleural effusion [ 16 , 17 ]. In the literature there are similar findings with explanation that it is due to suppresser activity of lymphocytes in peripheral blood, but also to the immunological reactivity of the pleural effusions [ 18 ].…”

Neopterin, Soluble lnterleukin-2 Receptor and Adenosine Deaminase Levels in Pleural Effusions

“…The highly elevated pleural fluid slL-2R values in TB and malignant pleurisy seems to be due to a high percentage o f activated lymphocytes in these effu sions [19][20][21]. It may reflect the activation o f local im mune status.…”

Prognostic role of immune microenvironment in pleural metastases from breast and lung adenocarcinomas

“…These studies mainly focused on T cells, many of them on the subset of T regulatory cells, with only rare reports for other cell types. Two studies (5,6) evaluating the counts of CD4 + and CD8 + cells, the first (5) in 9 pleural and 10 peritoneal metastatic effusions, the second (6) in 6 mesotheliomas, 9 lung carcinomas and 7 tuberculosis pleural, showed higher CD4 + cells counts and unchanged CD8 + counts for all these diseases compared to peripheral blood (5,6), while no differences were seen between the three disease groups (6). Interestingly, in two studies, one (7) with metastatic pleural effusions from variable primaries, and another from lung ADCs (8), T cells were mostly naive or of central memory, and not of effector type, thus suggesting a milieu of immune system escape in this tumor compartment.…”

Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Etiology

“…In patients with malignant effusions, we noticed increase of the values of CD3, CD4, CD8 and CD16 positive T cells in the pleural malignant fluid versus blood, but these changes were not significant due to different etiologies of malignancy. Some authors demonstrate increased CD4+ T lymphocyte subset in malignant pleural effusion [ 16 , 17 ]. In the literature there are similar findings with explanation that it is due to suppresser activity of lymphocytes in peripheral blood, but also to the immunological reactivity of the pleural effusions [ 18 ].…”

Neopterin, Soluble lnterleukin-2 Receptor and Adenosine Deaminase Levels in Pleural Effusions

“…The highly elevated pleural fluid slL-2R values in TB and malignant pleurisy seems to be due to a high percentage o f activated lymphocytes in these effu sions [19][20][21]. It may reflect the activation o f local im mune status.…”