Lymphocyte Oxidative DNA Damage and Plasma Antioxidants in Alzheimer Disease

Abstract

Markers of oxidative damage are increased in AD and correlate with decreased levels of plasma antioxidants. These findings suggest that lymphocyte DNA 8-OHdG content in patients with AD reflects a condition of increased oxidative stress related to a poor antioxidant status.

Serum apelin‐13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease

“…Mean TAS in the AD group was lower than in the control group, and a statistically significant positive correlation was observed between MMSE scores and TAS values of patients showing the relation of cognitive functions indicated by MMSE scores with TAS/TOS status of patients with AD. These findings were consistent with the results of other studies by Mecocci et al 25 and Minghetti et al 26 …”

Serum apelin‐13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease

“…Mean TAS in the AD group was lower than in the control group, and a statistically significant positive correlation was observed between MMSE scores and TAS values of patients showing the relation of cognitive functions indicated by MMSE scores with TAS/TOS status of patients with AD. These findings were consistent with the results of other studies by Mecocci et al 25 and Minghetti et al 26 …”

Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer's Disease

“…In accordance with our work, several other studies have reported decreased levels of vitamin E in the plasma of AD patients [6,48,62]. However, these studies also reported decreased levels of vitamin A and uric acid, which in our work appeared only slightly, although not significantly, reduced.…”

Carotenoid-Rich Brain Nutrient Pattern Is Positively Correlated With Higher Cognition and Lower Depression in the Oldest Old With No Dementia

“…This is further supported by the fact that nutrient concentrations and NP scores were not different between demented and non-demented subjects. Our exploratory findings also corroborate previous findings where serum levels of carotenoids are positively associated with better cognition in aging subjects (26,32,(57)(58)(59)(60). Specifically, higher serum lutein concentration was reported to be associated with better performance on language (32), which is similar to the correlation between NP2 and language score in this study.…”

Serum apelin‐13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease

“…Mean TAS in the AD group was lower than in the control group, and a statistically significant positive correlation was observed between MMSE scores and TAS values of patients showing the relation of cognitive functions indicated by MMSE scores with TAS/TOS status of patients with AD. These findings were consistent with the results of other studies by Mecocci et al 25 and Minghetti et al 26 …”

Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer's Disease

“…In accordance with our work, several other studies have reported decreased levels of vitamin E in the plasma of AD patients [6,48,62]. However, these studies also reported decreased levels of vitamin A and uric acid, which in our work appeared only slightly, although not significantly, reduced.…”

Carotenoid-Rich Brain Nutrient Pattern Is Positively Correlated With Higher Cognition and Lower Depression in the Oldest Old With No Dementia

“…This is further supported by the fact that nutrient concentrations and NP scores were not different between demented and non-demented subjects. Our exploratory findings also corroborate previous findings where serum levels of carotenoids are positively associated with better cognition in aging subjects (26,32,(57)(58)(59)(60). Specifically, higher serum lutein concentration was reported to be associated with better performance on language (32), which is similar to the correlation between NP2 and language score in this study.…”

Serum apelin‐13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease

“…Mean TAS in the AD group was lower than in the control group, and a statistically significant positive correlation was observed between MMSE scores and TAS values of patients showing the relation of cognitive functions indicated by MMSE scores with TAS/TOS status of patients with AD. These findings were consistent with the results of other studies by Mecocci et al 25 and Minghetti et al 26 …”

Peripheral Oxidative Damage in Mild Cognitive Impairment and Mild Alzheimer's Disease

“…In accordance with our work, several other studies have reported decreased levels of vitamin E in the plasma of AD patients [6,48,62]. However, these studies also reported decreased levels of vitamin A and uric acid, which in our work appeared only slightly, although not significantly, reduced.…”

Carotenoid-Rich Brain Nutrient Pattern Is Positively Correlated With Higher Cognition and Lower Depression in the Oldest Old With No Dementia

“…This is further supported by the fact that nutrient concentrations and NP scores were not different between demented and non-demented subjects. Our exploratory findings also corroborate previous findings where serum levels of carotenoids are positively associated with better cognition in aging subjects (26,32,(57)(58)(59)(60). Specifically, higher serum lutein concentration was reported to be associated with better performance on language (32), which is similar to the correlation between NP2 and language score in this study.…”