Lymphangiosarcoma and congenital lymphedema of the extremity

BACKGROUND Angiosarcoma arising in the irradiated breast after breast‐conserving therapy is being reported with increasing frequency. As more women undergo breast‐conserving therapy, the incidence can be expected to increase. Surgeons, medical oncologists, and radiation oncologists will be faced with difficult management decisions for this aggressive disease. METHODS A comprehensive review of all English‐language reports of angiosarcomas after breast‐conserving therapy was performed. Approximately 100 cases were reviewed for treatment details and outcome analysis was performed. RESULTS Surgical excision is associated with very high rates of disease recurrence (55 of 75 patients with at least 1 year of follow‐up; 73%). Local disease recurrences in the tumor bed or along the mastectomy scar are a component of almost all recurrences (96%). Distant metastases develop simultaneously or shortly after local recurrences. Hyperfractionated radiotherapy has successfully prevented local disease recurrences in a limited number of patients. CONCLUSIONS Angiosarcoma after breast‐conserving therapy is increasingly diagnosed in a small but significant portion of breast carcinoma survivors. The aggressive nature of this disease demands further investigation of adjuvant therapy to prevent recurrence of disease after surgery. Cancer 2003;97:1832–40. © 2003 American Cancer Society. DOI 10.1002/cncr.11277

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Angiosarcoma after breast‐conserving therapy

Monroe

Feigenberg

Mendenhall

2003

Cancer

206

224

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Vascular Tumours

Glicenstein¹,

Ohana²,

Leclercq³

1988

Tumours of the Hand

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Verruciform Xanthoma in Association with Milroy Disease and Leaky Capillary Syndrome

Wagner

2003

Pediatric Dermatology

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An 18-year-old Caucasian boy with Milroy disease involving the right leg presented with erythematous, smooth-topped, waxy papules on the dorsum of his right foot. A 12-year-old Caucasian girl with leaky capillary syndrome presented with hemorrhagic verrucous papules on the dorsum of the toes of both feet. Histopathologic analysis revealed changes consistent with xanthoma. Both patients were treated with leg compression, curettage, and electrodesiccation. Although similar papules have been described in the setting of lymphedema from other causes, this is the first report of verruciform xanthoma associated with Milroy disease or leaky capillary syndrome.

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Lymphangiosarcoma and congenital lymphedema of the extremity

Cited by 10 publications

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Angiosarcoma after breast‐conserving therapy

Angiosarcoma after breast‐conserving therapy

Vascular Tumours

Verruciform Xanthoma in Association with Milroy Disease and Leaky Capillary Syndrome

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