Lymph node metastasis of osteosarcomas

Vasiliev, N. V.

doi:10.17116/patol201678458-62

Cited by 9 publications

(3 citation statements)

References 44 publications

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“…These two types of metastasis might together reflect the divergent traits of metastasis of different bone sarcomas. Another important factor predictive of RLNM was larger tumor size (>12 cm), which has been reported to be a risk factor for RLNM of osteosarcoma (22). This reminds clinical surgeons that more attention should be paid to RLNM when resecting tumor with a large size.…”

Section: Discussionmentioning

confidence: 85%

Risk factors of regional lymph node (RLN) metastasis among patients with bone sarcoma and survival of patients with RLN-positive bone sarcoma

Dong¹,

Wu²,

Kang³

et al. 2021

Ann Transl Med

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Background: Regional lymph node metastasis (RLNM) has been reported to be a prognostic factor for poor survival outcomes of bone sarcoma. However, studies about risk factors for RLNM of bone sarcoma are extremely rare, and the outcome of such patients remains to be explored. We aimed to identify risk factors for RLNM of bone sarcoma and conduct survival analysis for patients with bone sarcoma with RLNM.Methods: A total of 10,641 patients confirmed of malignant bone sarcomas from 1983 to 2014 were identified from the Surveillance, Epidemiology, and End Results (SEER) database, with 311 being regional lymph node positive. Logistic regression analysis was used to identify risk factors for RLNM, while the Cox proportional hazards model and the Fine and Gray's regression model were used for survival analysis.Results: The proportion of RLNM was 6.0% in Ewing sarcoma, 2.5% in osteosarcoma and 1.1% in chondrosarcoma. Other bone tumors together had a RLNM rate of 4.2%. Risk factors identified by the logistic regression analysis for RLNM were male patients, primary tumor site, tumor type and size.The multivariate Cox regression analysis suggested age, race, distant metastasis, tumor type and surgical treatment to be prognostic factors for the overall survival of patients with RLNM. Taking non-cancerspecific death as a competing risk, however, we found only age between 30-60 years [sub-distribution hazard ratio (SHR), 1.528, 95% CI, 1.028-2.271; P=0.02], distant metastasis (SHR, 2.418, 95% CI, 1.682-3.474; P<0.001) and surgery treatment (SHR, 0.493, 95% CI, 0.339-0.718; P<0.001) remained significant for the cancer-specific survival in the Fine and Gray's regression model. Conclusions: Predictive factors for RLNM of bone sarcoma are sex, tumor site, type and size. In the presence of RKNM, only age, distant metastasis and surgery treatment are prognostic factors for the outcome of patients with bone sarcoma.

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Section: Discussionmentioning

confidence: 85%

Risk factors of regional lymph node (RLN) metastasis among patients with bone sarcoma and survival of patients with RLN-positive bone sarcoma

Dong¹,

Wu²,

Kang³

et al. 2021

Ann Transl Med

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“…Constitutional symptoms and lymph node metastasis are less common in osteosarcoma. Age ≥64 years; female sex; undifferentiated pleomorphic sarcoma, osteosarcoma, or chondrosarcoma; increased tumor depth; and primary tumor size are the risk factors of lymph node metastasis, which significantly reduces patient 5-year survival [ 4 ]. A detailed history taking is crucial to diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Persistent Shoulder Pain in Young Male: Osteosarcoma

Arinima

2018

Korean J Fam Med

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A 16-year-old Malay boy presented to Kota Bharu Health Care Centre, Kelantan, with left shoulder pain after sustaining a fall. On further history taking, it was noted that the pain preceded the fall by 1 month. The early changes of osteosarcoma were visible on an X-ray during the initial presentation; however, this was missed by the primary care doctors. Three months later, the patient presented with persistent pain in the left shoulder and was diagnosed with osteosarcoma.

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“…Uncontrolled local disease and subsequent recurrence occurs in about 33%‐69% of patients and is the most common cause of mortality. Lymph node metastasis is considered to comprise 4%‐11% of osteosarcomas . Because regional metastasis to the lymph nodes of the neck is rare, neck dissection is not mandatory and indicated only in the presence of clinically positive neck results.…”

Section: Current Treatment Of Oral Cancermentioning

confidence: 99%

Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients

Yura

Tada

Fujita

et al. 2019

Oral Science International

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Malignant tumors such as squamous cell carcinoma (SCC), malignant salivary gland tumor, mucosal melanoma, sarcoma, and lymphoma occur in the oral cavity. Among them, oral SCC accounts for 90%. The frequency of lymph node metastasis of oral SCC varies depending on the site of occurrence, which affects the prognosis. Surgery is the primary treatment for oral cancer, but when the tumor extends, postoperative radiation with or without chemotherapy is required. Photons including X-rays and γ-rays are the most widely used types of ionizing radiation in cancer radiotherapy. Particle radiotherapy using protons and carbon ions shows a highly focused dose distribution to tumor tissues. Carbon ion therapy is effective for salivary gland tumors, malignant melanomas, and sarcomas which are less susceptible to photons. Furthermore, boron neutron capture therapy with tumor selectivity is expected to further reduce damage to surrounding normal cells. The introduction of novel radiotherapy to current treatment might improve the prognosis of patients and organ preservation. K E Y W O R D S chemotherapy, oral cancer, particle radiotherapy, radiotherapy, surgery How to cite this article: Yura Y, Tada S, Fujita Y, Hamada M. Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients. Oral Sci Int. 2019;16:49-68. https://doi.

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Lymph node metastasis of osteosarcomas

Cited by 9 publications

References 44 publications

Risk factors of regional lymph node (RLN) metastasis among patients with bone sarcoma and survival of patients with RLN-positive bone sarcoma

Risk factors of regional lymph node (RLN) metastasis among patients with bone sarcoma and survival of patients with RLN-positive bone sarcoma

Persistent Shoulder Pain in Young Male: Osteosarcoma

Current treatment, particle radiotherapy, and boron neutron capture therapy for advanced oral cancer in patients

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