Lye corrosion carcinoma of the esophagus. A review of 63 cases

Appelqvist, P; Salmo, M

doi:10.1002/1097-0142(19800515)45:10<2655::aid-cncr2820451028>3.0.co;2-p

Cited by 231 publications

(72 citation statements)

References 9 publications

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“…The association between corrosion and carcinoma was probably causal in 5 women who developed oesophageal cancer 25-50 years after corrosive injury [7]. Clinical characteristics of patients who developed esophageal cancer after caustic injury included, mean age 35 to 51 years; average interval between caustic injury and development of esophageal cancer approximately 40 years; and cancers were located in the mid-esophagus [8].…”

Section: Discussionmentioning

confidence: 99%

Histopathological Profile of Caustic Esophageal Strictures on Chronic Endoscopic Dilatation: What is the Safe Limit??

Nagaich¹

2015

JCPCR

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IntroductionCaustic esophageal injury results from accidental ingestion of corrosive in children and intentional in adults [1]. The common causes are ingestion of strong alkali and highly concentrated acids. Once a stricture is identified, esophageal dilatation is initiated and gradually advanced to relieve dysphagia. Chronic inflammation and fibrosis leads to dysplasia which predisposes the epithelium to develop esophageal squamous cell carcinoma [2]. Chronology and incidence of appearance of carcinoma at the site of stricture, however, is a less well-recognized complication that may develop years after the original injury. There are no data from prospective surveillance programs. This study was conducted to study histopathology changes and dysplasia in caustic esophageal strictures on chronic dilatation. Material and MethodsThis study was conducted in Department of gastroenterology SMS medical college Jaipur. Patients with caustic esophageal strictures and above 03 years of age on chronic dilatation sessions of more than ten year duration were included after informed consent. Patient with fistulae, surgery, peptic stricture AbstractIntroduction: Corrosive injury related esophageal stricture has been cited as a risk factor for squamous cell carcinoma esophagus. There are no data from prospective surveillance programs. This study was planned to study histopathological changes and safety of chronic dilatation (mean duration 10.1 year) in reference to occurrence of dysplastic changes.

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Section: Discussionmentioning

confidence: 99%

Histopathological Profile of Caustic Esophageal Strictures on Chronic Endoscopic Dilatation: What is the Safe Limit??

Nagaich¹

2015

JCPCR

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“…There is one concern with this procedure, which is the possibility that carcinoma may develop in the damaged esophagus [16]. Thus, these patients require ongoing surveillance.…”

Section: Discussionmentioning

confidence: 99%

High dose intravenous methylprednisolone resolves esophageal stricture resistant to balloon dilatation with intralesional injection of dexamethasone

et al. 2008

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One of the most serious problems in patients with long-gap esophageal atresia or corrosive esophagitis is esophageal stricture, which may require esophageal resection and replacement. We describe two cases with persistent esophageal stricture successfully managed by high dose intravenous methylprednisolone following balloon dilatation. High-dose methylprednisolone with gradual tapering (daily 25, 15, 10, 5, 2 mg/kg for 4 days each) plus cimetidine and ampicillin for 1 week was intravenously administrated immediately after balloon dilatation of the esophageal stenosis. This was followed by oral prednisolone (daily 2, 1, 0.5 mg/kg for 1 week each) for persistent esophageal stricture. High dose intravenous methylprednisolone therapy was given to two patients. One patient was a 5-year-old boy with long-gap esophageal atresia who had undergone repair of the esophagus resulting in severe anastomotic stenosis of 3 cm in length. The other case was a 10-year-old boy with corrosive stenosis caused by alkali ingestion. Both patients had been requiring balloon dilatation of the esophagus with intralesional injection of dexamethasone every 3 weeks for more than 1 year to tolerate oral feeding. After the high-dose methylprednisolone protocol was initiated, the symptoms of dysphagia or choking dramatically improved in both patients, and they remained symptom-free for 8 and 7 months. There were complications of moon faces that resolved concomitantly with the withdrawal of oral prednisolone in both cases. High dose intravenous methylprednisolone in addition to intralesional injection of dexamethasone following balloon dilation is an effective therapeutic strategy for persistent esophageal strictures.

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“…Another dreaded long-term complication is the association of malignant potential in patients with strictures following alkali ingestion. 7 A step wise approach to a patient with history of corrosive ingestion. 8 Upper endoscopy examination should be performed in the first 24 to 48hours in all patients with history of corrosive ingestion permitting more precise therapeutic regimens and also for early discharge of patients with normal findings or minimal evidence of GI tract injury.…”

Section: Introductionmentioning

confidence: 99%

Clinical profile and the outcome of corrosive injury of GI tract

2017

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Background: Corrosive substances are common household substances that can be ingested either accidentally or intentionally with suicidal intent. The present study was conducted to analyse the clinical profile of 50 cases of corrosive injury of GI tract and to analyse the outcome of 50 cases of corrosive injury of GI tract.Methods: The Cross-sectional study was conducted on 50 cases admitted in the toxicology ward in Rajiv Gandhi Government General Hospital, madras medical college, Chennai over a period of six months. Patients with history of corrosive ingestion presenting within 24 hours of ingestion subjected to Upper GI endoscopy within 24 hours of admission. Patients presenting after 24 hours, with respiratory distress, suspected perforation either radiologically clinically and normal findings in Upper GI endoscopy were excluded. The patients were serially followed and were subjected for a re-look upper GI endoscopy after 6 weeks and the findings were compared.Results: Corrosive ingestion was more common in the age group 20-30 years and more common in males. Acid ingestion was almost twice as common as alkali ingestion. Suicidal ingestion was the most common circumstance of consumption and associated with higher grade of injury. Patients with ingestion of more than 50 ml had higher grades of injury and also were at higher risk of strictures. The spectrum of injury to the GI tract revealed esophageal injury of grade II b to be the most common finding with the duodenum being spared in majority of the cases.Conclusions: In our study, Patients with ingestion of more than 50ml had higher grades of injury and also were at higher risk of strictures. While the lesser grade injuries (0, I, IIa) were associated with complete recovery with no sequelae, the more severe grades (IIb and IIIa) were associated with higher incidence of strictures especially the circumferential lesions. Oesophageal strictures are commonly associated with suicidal corrosive ingestion. All patients with corrosive ingestion should be subjected to early UGIE and after 6 weeks to identify stricture formation.

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Lye corrosion carcinoma of the esophagus. A review of 63 cases

Cited by 231 publications

References 9 publications

Histopathological Profile of Caustic Esophageal Strictures on Chronic Endoscopic Dilatation: What is the Safe Limit??

Histopathological Profile of Caustic Esophageal Strictures on Chronic Endoscopic Dilatation: What is the Safe Limit??

High dose intravenous methylprednisolone resolves esophageal stricture resistant to balloon dilatation with intralesional injection of dexamethasone

Clinical profile and the outcome of corrosive injury of GI tract

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