Lycopene suppresses the lipopolysaccharide‐induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen‐activated protein kinases and nuclear factor‐<i>κ</i>B

Kim, Gi‐Young; Kim, Jong-Hyun; Ahn, Soon‐Cheol; Lee, Hee-Jeong; Moon, Dong‐Oh; Lee, Chang-Min; Park, Yeong‐Min

doi:10.1111/j.1365-2567.2004.01945.x

Cited by 125 publications

(84 citation statements)

References 50 publications

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“…Lycopene suppresses inflammation in several tissues, inhibiting the formation of proinflammatory cytokines and chemokines in macrophages (Lee et al 2012;Marcotorchino et al 2012), in addition to controlling chronic immune and inflammatory processes and also delaying the maturation of dendritic cells (Kim et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Lycopene affects the immune responses of finishing pigs

Fachinello

Fernandes

Souto

et al. 2017

Italian Journal of Animal Science

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The objective of this study was to evaluate dietary lycopene levels on the immune responses of finishing pigs. Forty barrows and 40 gilts, averaging 75.04 ± 1.6 kg of initial weight, were allotted in a randomised blocks design arranged in a 2 Â 5 factorial scheme, consisting of two sexes (males and females) and five lycopene levels (0, 12.5, 25.0, 37.5, 50.0 mg/kg of diet). The studied parameters were submitted to the statistical analysis adopting 5% significance. Increasing lycopene in pig diets increased the plasma albumin (p ¼ .023). There was no interaction (p > .05) between sex and lycopene on the leukocyte profile or haematocrit concentration. As lycopene levels increased in the diet, the lymphocyte concentration increased linearly (p ¼ .045). The neutrophil concentration and the neutrophil:lymphocyte ratio were affected (p < .05) by dietary lycopene levels, showing a lower neutrophils concentration at 17.49 mg lycopene/kg of diet, and the lowest neutrophil:lymphocyte ratio was observed at 16.46 mg/kg. Eosinophils were also affected (p ¼ .050) by lycopene supplementation, estimating the greater response by adding 22.69 mg lycopene/kg of diet. There was an interaction (p ¼ .011) between the blood collection period and lycopene levels for anti-BSA IgG, resulting in higher production of anti-BSA IgG with the supplementation of up to 20.06 mg of lycopene/kg of diet. Dietary lycopene supplementation for finishing pigs affected the cellular and humoral immune response, and the highest anti-BSA IgG production was achieved by supplementing 20.06 mg lycopene/kg of diet. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Lycopene affects the immune responses of finishing pigs

Fachinello

Fernandes

Souto

et al. 2017

Italian Journal of Animal Science

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“…Evidence from in vitro studies demonstrate that components of the NF-κB and mitogen-activated protein kinase signalling pathways are prime targets of antioxidants, as illustrated in Fig. 1 (68)(69)(70) . Epigallocatechin gallate, lycopene and vitamin C impede NF-κB signalling, by targeting IKK and attenuate phosphorylation of extracellular signal related kinase, p-38 and JNK (67)(68)(69)71) .…”

Section: Cellular Processesmentioning

confidence: 99%

“…1 (68)(69)(70) . Epigallocatechin gallate, lycopene and vitamin C impede NF-κB signalling, by targeting IKK and attenuate phosphorylation of extracellular signal related kinase, p-38 and JNK (67)(68)(69)71) . α-Tocopherol, in conjunction with vitamin D 3 ameliorates IL-6 production as well as increasing mRNA and protein expression of adiponectin in 3T3-L1 adipocytes (71,72) .…”

Section: Cellular Processesmentioning

confidence: 99%

Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood

et al. 2016

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Obesity-related metabolic conditions such as insulin resistance (IR), type 2 diabetes and CVD share a number of pathological features, one of which is metabolic-inflammation. Metabolic-inflammation results from the infiltration of immune cells into the adipose tissue, driving a pro-inflammatory environment, which can induce IR. Furthermore, resolution of inflammation, an active process wherein the immune system counteracts pro-inflammatory states, may be dysregulated in obesity. Anti-inflammatory nutritional interventions have focused on attenuating this pro-inflammatory environment. Furthermore, with inherent variability among individuals, establishing at-risk populations who respond favourably to nutritional intervention strategies is important. This review will focus on chronic low-grade metabolic-inflammation, resolution of inflammation and the putative role anti-inflammatory nutrients have as a potential therapy. Finally, in the context of personalised nutrition, the approaches used in defining individuals who respond favourably to nutritional interventions will be highlighted. With increasing prevalence of obesity in younger people, age-dependent biological processes, preventative strategies and therapeutic options are important to help protect against development of obesity-associated co-morbidities.

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“…40 The increase in the phenotypic and functional maturation of dendritic cells by lycopene was also reported. 41 …”

Section: Health Protective Effects Of Lycopenementioning

confidence: 99%

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

Bacanlı¹,

Başaran²,

Başaran³

2017

tjps

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It is well known that free oxygen radicals play an important role in the pathogenesis of several chronic disorders. Antioxidants are known as potential scavengers of reactive oxygen species that can protect biologic membranes against oxidative damage. Recent interest in phytochemicals has increased because of their protective effects against free oxygen radicals. Lycopene, which belongs to the carotenoid family, is the most effective singlet oxygen scavenger in vitro of all the carotenoids. Foods that contain lycopene and related supplements have been reported to prevent chronic diseases including cancer, asthma, and cardiovascular disorders. The aim of the article was to give a brief review of the antioxidant properties and beneficial health effects of lycopene.

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Lycopene suppresses the lipopolysaccharide‐induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen‐activated protein kinases and nuclear factor‐κB

Cited by 125 publications

References 50 publications

Lycopene affects the immune responses of finishing pigs

Lycopene affects the immune responses of finishing pigs

Impact of anti-inflammatory nutrients on obesity-associated metabolic-inflammation from childhood through to adulthood

Lycopene: Is it Beneficial to Human Health as an Antioxidant?

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