volume 10, issue 8, P2016-2036 2018
DOI: 10.18632/aging.101526
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Xingting Liu, Xin Lin, Siyu Zhang, Changquan Guo, Jian Li, Yuling Mi, Caiqiao Zhang

Abstract: After 480 days of age, high-producing hens are likely to be subject to ovarian aging, mainly due to oxidative stress. In this study, the amelioration of ovarian aging in chickens, using a plant antioxidant, lycopene, was investigated. The activity of the Nrf2/HO-1 pathway in chicken ovaries at different ages (90, 150, 280 and 580 days old) were compared to elucidate any age-related changes. Subsequently, the putative attenuating effect of lycopene (100 ng/mL) on ovarian aging was evaluated through the establis…

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