2018
DOI: 10.18632/aging.101526
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Abstract: After 480 days of age, high-producing hens are likely to be subject to ovarian aging, mainly due to oxidative stress. In this study, the amelioration of ovarian aging in chickens, using a plant antioxidant, lycopene, was investigated. The activity of the Nrf2/HO-1 pathway in chicken ovaries at different ages (90, 150, 280 and 580 days old) were compared to elucidate any age-related changes. Subsequently, the putative attenuating effect of lycopene (100 ng/mL) on ovarian aging was evaluated through the establis… Show more

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Cited by 64 publications
(56 citation statements)
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References 53 publications
(67 reference statements)
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“…Lycopene plays an antioxidant role in the aging chicken ovary through the Nrf2/ho-1 pathway (X. Liu et al, 2018). Red yeast rice can inhibit cell senescence and oxidative stress in high glucoseinduced proangiogenic cells by activating HO-1 (J. T. Liu, Chen, Chen, Man, & Chen, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Lycopene plays an antioxidant role in the aging chicken ovary through the Nrf2/ho-1 pathway (X. Liu et al, 2018). Red yeast rice can inhibit cell senescence and oxidative stress in high glucoseinduced proangiogenic cells by activating HO-1 (J. T. Liu, Chen, Chen, Man, & Chen, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…The aging-associated decline in fertility has shown correlation with dysregulated pro- and antioxidant signaling [ 11 , 23 , 24 ]. Studies utilizing various animal models of induced ovarian oxidative stress provide evidence that antioxidant supplementation combats oxidative damage in the ovary [ 25 , 26 , 27 , 28 , 29 , 30 ].…”
Section: Introductionmentioning
confidence: 99%
“…In a study on poultry, lycopene was found to inhibit both natural ovarian aging and d-galactose-induced ovarian aging. 26 In 1992, Stahl et al reported that the measurements of beta-carotene and lycopene levels from the diet in human plasma and 7 different human tissues (liver, adrenal gland, testis, kidney, ovary, and fat and brain stem tissue). 27 In this study, it was reported that the lycopene level was found to be the lowest in the ovarian tissue.…”
Section: Discussionmentioning
confidence: 99%