LXRβ is involved in the control of platelet production from megakaryocytes

Wan, Yu-wei; Liu, Wang; Feng, Mu-Ting; Pu, Jun; Zhuang, Shaowei; He, Ben; Li, Xuan

doi:10.1016/j.bcmd.2021.102568

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…LXRs (Liver X Receptor α and β) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors (Hammer et al, 2021). Activation of LXRs could induce gene expression related to cholesterol excretion, such as ABCG (Song, Yan, Wang, & Lou, 2021;Wan et al, 2021). LXRs regulated the cholesterol metabolism of cells, affected the inflammatory response, and inhibited the expression of inflammatory genes (Kongkwamcharoen, Itharat, Pipatrattanaseree, & Ooraikul, 2021).…”

Section: Introductionmentioning

confidence: 99%

Lycorine destabilizes lipid rafts to inhibit inflammation via LXRα signal in the lung of mice

Wang,

Zhang,

et al. 2024

Preprint

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Background and Purpose: Lycorine is an alkaloid that was in the bulb of the genus Lycoris. It has properties of anti-inflammatory. This study aimed to investigate the molecular mechanism by which lycorine can reduce acute lung injury (ALI). Experimental Approach: ALI model was established by intranasal injection of lipopolysaccharide (LPS). In vitro, A549 cells were treated with LPS and pretreated with lycorine for 1 hour. Key Results: The results showed that lycorine reduced histopathological changes in lung, myeloperoxidase (MPO) activity, and the production of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in mice. Lycorine dose-dependently inhibited the production of TNF-α, IL-1β, and IL-6. It also inhibited the transmission of TLR4/NF-κB passway in LPS-stimulated A549 cells. Lycorine increased cholesterol efflux through the activated LXRα-ABCA1/ABCG pathway. Lycorine has a good binding ability with LXRα. After adding the LXRα inhibitor, the anti-inflammatory effect of lycorine was eliminated. Conclusion and Implications: Lycorine can reduce ALI that was induced by lipopolysaccharide. The anti-inflammatory mechanism of lycorine is related to the up-regulation of the LXRα-ABCA1/ABCG pathway, which inhibits TLR4-mediated inflammation by increasing cholesterol efflux and reducing TLR4 transport to lipid rafts.

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Section: Introductionmentioning

confidence: 99%