2021
DOI: 10.3390/molecules26216452
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Abstract: Cancer stem cells (CSCs) are subpopulations of tumor masses with unique abilities in self-renewal, stemness maintenance, drug resistance, and the promotion of cancer recurrence. Recent studies have suggested that breast CSCs play essential roles in chemoresistance. Therefore, new agents that selectively target such cells are urgently required. Reactive oxygen species (ROS)-producing enzymes are the reason for an elevated tumor oxidant status. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcri… Show more

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Cited by 20 publications
(11 citation statements)
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References 51 publications
(53 reference statements)
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“…T. of fi cinale is distributed worldwide and is the subject of more than 70% of pharmacological references to Taraxacum . Phytochemical investigations have revealed that dandelion contains chicoric acid, flavonoids, lactones, phenolics, polysaccharides, sesquiterpenes, and triterpenes [ 10 , 11 , 14 , 15 , 17 , 20 ]. Importantly, several bioactive compounds extracted from various Taraxacum species, including T. mongolicum and T. formosanum , remain to be identified.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…T. of fi cinale is distributed worldwide and is the subject of more than 70% of pharmacological references to Taraxacum . Phytochemical investigations have revealed that dandelion contains chicoric acid, flavonoids, lactones, phenolics, polysaccharides, sesquiterpenes, and triterpenes [ 10 , 11 , 14 , 15 , 17 , 20 ]. Importantly, several bioactive compounds extracted from various Taraxacum species, including T. mongolicum and T. formosanum , remain to be identified.…”
Section: Discussionmentioning
confidence: 99%
“…The identification of active compounds and working mechanisms against diseases could enable these herbal traditional medicines to emerge as commercial herbs. However, only a small proportion of dandelion species are currently being scientifically studied [ 10 , 11 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. The genus Taraxacum has been used to treat breast cancer in traditional folk medicine [ 15 , 17 , 18 , 19 , 20 , 21 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Luteolin significantly inhibited tumor cell migration to reduce VEGF levels and block VEGF receptors, with IC 50 of 10 µM in vitro and in vivo [161]. In addition, luteolin from Taraxacum officinale extract can inhibit Nrf2 in breast cancer stemness (Cripto1, CD44, ALDH1, ABCG2, NANOG, OCT4, and Sirt3) and chemoresistance, with IC 50 value 1 µM in an MDA-MB-231 cell line in vitro study [162].…”
Section: Luteolinmentioning
confidence: 97%
“…On the other hand, the activity of NRF2 is the key to chemotherapy resistance in MCF7 BC cells [119] . The chemotherapeutic agents, such as luteolin, enhanced the chemosensitivity through downregulating the NRF2 expression [120] , suggesting that a low NRF2 signature may be key to cellular sensitivity to both chemical carcinogenic stimuli and the cytotoxicity of commonly used chemotherapeutic drugs in established BC [121] .…”
Section: Pentose Phosphate Pathway (Ppp)mentioning
confidence: 99%