Luteolin, a flavonoid, as an anticancer agent: A review

Imran, Muhammad; Rauf, Abdur; Abu-Izneid, Tareq; Nadeem, Muhammad; Shariati, Mohammad Ali; Khan, Imtiaz; Imran, Ali; Orhan, İlkay Erdoğan; Rizwan, Muhammad; Atif, Muhammad; Gondal, Tanweer Aslam; Mubarak, Mohammad S.

doi:10.1016/j.biopha.2019.108612

Cited by 531 publications

(308 citation statements)

References 88 publications

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“…in addition, this compound associated with interferon gamma (IFNγ) is a good combination therapy against cervical cancer cell line HeLa and SiHa [25]. According to numerous studies, Luteolin is known for it potent prevention and inhibition against cervical cancer [26]. Quercetin decreased cervical cancer cell proliferation and induced cell death [27].…”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity Potential of Nelsonia canescens (Lam.) Spreng Extracts against Cervical Cancer Cell Lines

Ouattara¹,

Alphonsine²,

Guenné³

et al. 2019

SJBR

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Nelsonia canescens is a small perennial herb widely used in Burkina Faso traditional medicine for the treatment of any diseases. In the present study, the purpose was to investigate the potential cytotoxicity and selectivity of different extracts from N. canescens on human cervical cancer HeLa and SiHa cell lines. MTT assay revealed higher cytotoxic activity of methanol extract in a dose-dependent manner against both HeLa and SiHa cells with respective IC 50 values of 21.72 ± 0.08 g/mL and 25.30 ± 0.44 g/mL. Methanol extract (ME) showed the best selectivity index value of 7.93 ± 0.03 with HeLa cell line and Ethyl acetate extract (EAE) showed the best selectivity index value of 7.48 ± 0.05 with SiHa. The potential cytotoxicity and selectivity of N. canescens extracts against HeLa and SiHa cells line suggest that this species could be exploited further as a potential lead in cervical cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Cytotoxicity Potential of Nelsonia canescens (Lam.) Spreng Extracts against Cervical Cancer Cell Lines

Ouattara¹,

Alphonsine²,

Guenné³

et al. 2019

SJBR

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“…Luteolin inhibits cell growth by regulating the cell cycle in several cancers . A member of the Cip/Kip family, p21 shares an N‐terminal domain that binds cyclins and cyclin‐dependent kinases (CDK) .…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoids are polyphenolic compounds found in fruits or vegetables that are believed to provide a health benefit. Luteolin, a flavonoid found in perilla, parsley and green peppers, scavenges ROS . Luteolin shows an anti–cancer effect in a variety of cancers, including colon, pancreatic, prostate and lung cancer, and has anti–oxidative, anti–inflammatory and anti–allergic properties .…”

Section: Introductionmentioning

confidence: 99%

“…Luteolin, a flavonoid found in perilla, parsley and green peppers, scavenges ROS . Luteolin shows an anti–cancer effect in a variety of cancers, including colon, pancreatic, prostate and lung cancer, and has anti–oxidative, anti–inflammatory and anti–allergic properties . We have previously found that luteolin has a preventive role in non–alcoholic steatohepatitis‐related hepatocarcinogenesis through suppression of hepatic ROS accumulation and NF‐κB signaling .…”

Section: Introductionmentioning

confidence: 99%

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Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway

et al. 2020

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Luteolin is a natural flavonoid with strong anti-oxidative properties that is reported to have an anti-cancer effect in several malignancies other than bladder cancer. In this study, we describe the effect of luteolin on a human bladder cancer cell line, T24, in the context of the regulation of p21, thioredoxin-1 (TRX1) and the mechanistic target of rapamycin (mTOR) pathway. Luteolin inhibited cell survival and induced G2/M cellcycle arrest, p21 upregulation and downregulation of phospho(p)-S6, which is downstream of mTOR signaling. Luteolin also upregulated TRX1 and reduced intracellular reactive oxygen species production. In a subcutaneous xenograft mouse model using the rat bladder cancer cell line, BC31, tumor volumes were significantly decreased in mice orally administered luteolin compared to control. Immunohistochemical analysis revealed that increased p21 and decreased p-S6 expression were induced in the luteolin treatment group. Moreover, in another in vivo N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced rat bladder cancer model, the oral administration of luteolin led to a trend of decreased bladder tumor dimension and significantly decreased the Ki67-labeling index and p-S6 expression. Furthermore, the major findings on the metabolism of luteolin suggest that both plasma and urine luteolin-3ʹ-O-glucuronide concentrations are strongly associated with the inhibition of cell proliferation and mTOR signaling. Moreover, a significant decrease in the squamous differentiation of bladder cancer is attributed to plasma luteolin-3ʹ-glucuronide concentration. In conclusion, luteolin, and in particular its metabolized product, may represent another natural product-derived therapeutic agent that acts against bladder cancer by upregulating p21 and inhibiting mTOR signaling. K E Y W O R D Sanimal model, bladder cancer, chemoprevention, mTOR, oxidative stress

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“…They are extensively found in various plants and act as an antimicrobial agent (Xu, Bailly‐Maitre, & Reed, ). Several epidemiological studies have demonstrated that the consumption of flavonoids is associated with decreased level of pathological conditions, particularly cancer (Imran et al, ; Yao et al, ). Therefore, many investigations have been performed to manifest the great pharmacological effects of members of flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

Ashrafizadeh

Tavakol

Ahmadi

et al. 2019

Phytotherapy Research

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Regulated cell death (RCD) guarantees to preserve organismal homeostasis. Apoptosis and autophagy are two major arms of RCD, while endoplasmic reticulum (ER) as a crucial organelle involved in proteostasis, promotes cells toward autophagy and apoptosis. Alteration in ER stress and autophagy machinery is responsible for a great number of diseases. Therefore, targeting those pathways appears to be beneficial in the treatment of relevant diseases. Meantime, among the traditional herb medicine, kaempferol as a flavonoid seems to be promising to modulate ER stress and autophagy and exhibits protective effects on malfunctioning cells. There are some reports indicating the capability of kaempferol in affecting autophagy and ER stress. In brief, kaempferol modulates autophagy in noncancerous cells to protect cells against malfunction, while it induces cell mortality derived from autophagy through the elevation of p-AMP-activated protein kinase, light chain-3-II, autophagy-related geness, and Beclin-1 in cancer cells. Noteworthy, kaempferol enhances cell survival through C/EBP homologous protein (CHOP) suppression and GRP78 increment in noncancerous cells, while it enhances cell mortality through the induction of unfolding protein response and CHOP increment in cancer cells. In this review, we discuss how kaempferol modulates autophagy and ER stress in noncancer and cancer cells to expand our knowledge of new pharmacological compounds for the treatment of associated diseases. K E Y W O R D S apoptosis, autophagy, cell death, endoplasmic reticulum stress, flavonoid, kaempferol

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Luteolin, a flavonoid, as an anticancer agent: A review

Cited by 531 publications

References 88 publications

Cytotoxicity Potential of Nelsonia canescens (Lam.) Spreng Extracts against Cervical Cancer Cell Lines

Cytotoxicity Potential of Nelsonia canescens (Lam.) Spreng Extracts against Cervical Cancer Cell Lines

Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

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