Luteinizing Hormone Releasing Hormone Enhances Proceptivity in a Primate

Kendrick, Keith M.; Dixson, Alan F.

doi:10.1159/000124218

Cited by 46 publications

(12 citation statements)

References 24 publications

(38 reference statements)

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“…In female rats, GnRH can facilitate lordosis behavior [29,30] and anti-GnRH injected into the mid-brain central gray [31] or the lateral ventricles [32] caused a blockage or reduction of the behavior. Moreover, GnRH influences sexual behavior in monkeys [33] and horses [34]. The present results suggest that GnRH also influences a bovine sexual behavior, standing estrus.…”

Section: Discussionsupporting

confidence: 57%

Gonadotropin-Releasing Hormone in Third Ventricular Cerebrospinal Fluid of the Heifer During the Estrous Cycle1

Yoshioka

Suzuki

Arai

et al. 2001

Biology of Reproduction

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The release profile of GnRH in cerebrospinal fluid (CSF) and its correlation with LH in peripheral blood of ovary-intact heifers during the estrous cycle were investigated. A silicon catheter was placed into the third ventricle of six heifers using ultrasonography. During the mid-luteal phase, the heifers were injected with prostaglandin F(2alpha) to induce luteolysis. Surges of CSF GnRH (66.7 h after prostaglandin F(2alpha) administration) and peripheral LH (66.3 h) occurred simultaneously and were coincident with the onset of estrus (67.0 h). Duration of elevated GnRH concentration considerably overlapped with the estrous phase in each of the heifers. Mean pulse frequencies of both GnRH and LH were significantly higher during the proestrous and early luteal phases than during the mid-luteal phase, while mean concentration and pulse amplitude of both GnRH and LH were not different between these three phases. Of all the GnRH pulses identified, more than 80% were accompanied by an LH pulse during the proestrous and early luteal phases. However, the proportion of GnRH pulses that were coincident with an LH pulse during the mid-luteal phase decreased to 60%. The results clearly demonstrate that a dynamic (pulse) and longer-term (surge) changes of GnRH release into CSF are physiologically expressed during the estrous cycle in heifers, and the pattern of pulsatile GnRH secretion in heifers depends upon their estrous cycle.

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Section: Discussionsupporting

confidence: 57%

Gonadotropin-Releasing Hormone in Third Ventricular Cerebrospinal Fluid of the Heifer During the Estrous Cycle1

Yoshioka

Suzuki

Arai

et al. 2001

Biology of Reproduction

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“…A seasonal difference in both nongonadal and E, -negative feedback-inhibiting LH occurs in outdoor-housed female rhesus monkeys (Wilson et al, 1986a), possibly through a reduction of endogenous LH-releasing hormone (LHRH) release during the summer months. A single injection of LHRH potentiates the lordosis response in E, -primed rats (Moss and McCann, 1973;Pfaff, 1973;Riskind and Moss, 1979) and enhances solicitational displays in ovariectomized, E, -implanted common marmosets (Kendrick and Dixson, 1985). There is also some evidence that LHRH facilitates sexual arousal in impotent (Benkert et al, 1975) and normal (Evans and Distiller, 1979) men.…”

Section: Discussionmentioning

confidence: 98%

The Effect of Season on the Induction of Sexual Behavior by Estradiol in Female Rhesus Monkeys1

Pope¹,

Wilson²,

Gordon³

1987

Biology of Reproduction

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Rhesus monkeys housed in an outdoor environment are seasonal breeders, with ovulations and concomitant sexual behavior limited to the fall and winter months. To determine if there is a seasonal difference in the capacity of physiological levels of estradiol (E2) to induce sexual behavior in ovariectomized rhesus monkeys housed outdoors, subjects living in a social group were treated with subcutaneous E2 implants in a counter-balanced design during the nonbreeding season (May-July) and during the breeding season (September-November). Serum E2 levels were monitored by obtaining blood samples twice a week. Three levels of E2 were studied: baseline (less than 30 pg/ml), follicular (100 pg/ml), and periovulatory (200 pg/ml). Two of five adult males in the group were injected with human chorionic gonadotropin (hCG) twice a week to insure that males with high testosterone levels were present during each season. Focal observations of behavior of 15 minutes' duration on each subject were conducted 5 days per week, with frequencies and durations of social, sexual, and solitary behaviors recorded. Concomitant 2-h group scans were made to record all occurrences of mounting behavior. Neither heterosexual serial mounting nor seminal plugs were ever observed in E2-treated females during the summer months. In contrast, copulation and seminal plugs were observed in subjects at both treatment levels during the fall. While E2-treated females engaged in homosexual mounting behavior during both summer and fall, E2 treatment resulted in heterosexual copulation only during the fall. Changes in patterns of social behavior paralleled changes in sexual behavior and were significantly affected by treatment and season, with more male-female interactions during the fall months.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…One mechanism that may be important for enhancing LHRH release is hypothalamic stimulation by male pheromonal cues via vomeronasal and amygdala projections (Johns et al, 1978;Saito and Moltz, 1986;Rajendren et al, 1990). In primates, on the other hand, LHRH has been shown to facilitate proceptive rather than receptive behaviours (Kendrick and Dixson, 1985). It is therefore possible that NA release within the sheep MBH could be facilitating both behavioural and endocrine responses to sensory cues from males through modulating LHRH.…”

Section: Discussionmentioning

confidence: 99%

Male Faces and Odours Evoke Differential Patterns of Neurochemical Release in the Mediobasal Hypothalamus of the Ewe During Oestrus: An Insight Into Sexual Motivation?

Fabre-Nys

Ohkura

Kendrick

1997

Eur J of Neuroscience

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During behavioural oestrus female sheep, like females of many species, become both attracted to and sexually receptive towards males, whereas at other times they will avoid them. The mediobasal hypothalamus is the main site for the feedback action of sex steroids to induce sexual behaviour in the sheep and in previous studies we have shown that noradrenaline and serotonin are released in this region during sexual interactions with males. The current study investigated whether such changes are specific to interactions with males and if visual or olfactory cues or somatosensory stimulation during mating are critical. In vivo microdialysis sampling was carried out in the mediobasal hypothalamus of ovariectomized ewes submitted to artificial oestrous cycles. Release of monoamines and amino acid transmitters was first measured in animals during and after oestrus when they were exposed to interactions with either males or females or presentation of food. Noradrenaline concentrations only increased significantly when the females were in oestrus and interacted with males irrespective of whether intromissions were permitted. Females were then exposed to visual (faces) or odour (a home pen) cues from males or to the males themselves. Slide images of male faces increased concentrations of amines, glutamate and GABA during early oestrus, when females spent most time looking at them. During late oestrus noradrenaline, glutamate and GABA concentrations also increased in response to the male faces but no transmitter changes were seen during the luteal phase or at any time where the females were exposed to female faces, or inverted male faces. Exposure to male odour produced a lower increase in noradrenaline concentrations when females were in early oestrus but marked increases 20 and 30 min after exposure to male odours in late oestrus. No other transmitters were affected. Exposure to a male and mating with him when females were in early or late oestrus produced increased noradrenaline concentrations similar to those seen with face stimuli alone although other neurotransmitters were unaffected. These results show that noradrenaline, and to a lesser extent dopamine, serotonin, glutamate and GABA release in the mediobasal hypothalamus, can be modulated specifically in the oestrous female by sensory information coming from the male during oestrus. The differential effects of male cues during early and late oestrus suggest their involvement in (i) proceptive or anticipatory sexual responses shown by the female to male cues, and (ii) receptive sexual responses, and suggest that the mediobasal hypothalamus plays a key role in the integration of hormonal action on sexual motivation and processing of sensory information during oestrus.

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Luteinizing Hormone Releasing Hormone Enhances Proceptivity in a Primate

Cited by 46 publications

References 24 publications

Gonadotropin-Releasing Hormone in Third Ventricular Cerebrospinal Fluid of the Heifer During the Estrous Cycle1

Gonadotropin-Releasing Hormone in Third Ventricular Cerebrospinal Fluid of the Heifer During the Estrous Cycle1

The Effect of Season on the Induction of Sexual Behavior by Estradiol in Female Rhesus Monkeys1

Male Faces and Odours Evoke Differential Patterns of Neurochemical Release in the Mediobasal Hypothalamus of the Ewe During Oestrus: An Insight Into Sexual Motivation?

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