Luteinized Cysts in Ovaries of Infants Born of Diabetic Mothers

Follicular ovarian cysts in stillbirths and neonates.

“…These are shown in Table III and are difficult to interpret due to the initial bias in selecting cases where the ovary was sampled. It appears, however, that a high proportion of the female infants of diabetic mothers and those where the pregnancy was complicated by rhesus isoimmunization have multiple follicular ovarian cysts, and this agrees with the findings of Ahlvin and Bauer (1957) and Pryse-Davies and Dewhurst (1971).…”

“…In some of the situations where a greater frequency of multiple cysts may be expected, like maternal diabetes and rhesus isoimmunization (Ahlvin and Bauer, 1957;Pryse-Davies and Dewhurst, 1971), placental enlargement is known to occur and this might be sufficient to explain the raised levels of chorionic gonadotrophin (Loraine and Mathew, 1953;McCarthy and Pennington, 1964;Connon, 1964). High levels of chorionic gonadotrophin have been described in pre-eclamptic toxaemia (Loraine and Mathew, 1950) and toxaemia of pregnancy has been tentatively associated with theca luteinization of the newborn ovary (Govan and Mukherjee, 1950).…”

Perinatal aspects of pregnancy complicated by fetal ovarian cyst

“…This strongly suggests that the true incidence of fetal ovarian cysts may be somewhat greater than earlier supposed particularly since the present series was collected in a relatively short period and from a relatively small population. Fortunately, the normal course of these cysts most often seems to be postnatal involution and regression [1,3]. This also was noted in our cases.…”

Follicular Development in the Infant Human Ovary

“…The high incidence of antral follicles in the ovaries of newborn girls appears to be unrelated to any pathological state in mother or child. Ahlvin & Bauer (1957) suggested a relationship between the presence of antral follicles in the newborn ovary and diabetes in the mother, but this was not supported by the more extensive survey of Kraus & Neubecker (1962). Furthermore, Spivak (1934) and Ober & Bernstein (1955) found no correlation between hyperplasia and hypertrophy of the newborn uterine endometrium and the presence of antral follicles in the ovary.…”