1995
DOI: 10.1001/archderm.131.5.617b
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Lupus pernio: successful treatment with a potent topical corticosteroid

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Cited by 12 publications
(11 citation statements)
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“…95 Halobetasol propionate 0.05% ointment applied twice daily caused flattening but not resolution of lupus pernio papules in another patient. 96 In other reports that documented clearing of sarcoidosis lesions with topical Intralesional injections of triamcinolone acetonide at concentrations of 3 to 20 mg/mL, repeated every 3 to 4 weeks, deliver the corticosteroid to the reticular dermis, and may be more effective than topical preparations. 97,98 However, topical or intralesional corticosteroids are impractical for cases with widespread lesions.…”
Section: Therapymentioning
confidence: 99%
“…95 Halobetasol propionate 0.05% ointment applied twice daily caused flattening but not resolution of lupus pernio papules in another patient. 96 In other reports that documented clearing of sarcoidosis lesions with topical Intralesional injections of triamcinolone acetonide at concentrations of 3 to 20 mg/mL, repeated every 3 to 4 weeks, deliver the corticosteroid to the reticular dermis, and may be more effective than topical preparations. 97,98 However, topical or intralesional corticosteroids are impractical for cases with widespread lesions.…”
Section: Therapymentioning
confidence: 99%
“…High-potency topical steroids (clobetasol, halobetasol, betamethasone) applied once to twice daily can lead to clinical resolution of disease. 127,128 Intralesional injections (triamcinolone, 5-40 mg) also can be used for thicker plaques to provide additional penetration. 129 The major risks of these medications, especially when used on thin skin (such as the face) include atrophy, dyspigmentation, and development of telangiectasias.…”
Section: Differential Diagnosismentioning
confidence: 99%
“…Other potential side effects of methotrexate include hepatic toxicity, gastrointestinal disturbances, and hypersensitivity pneumonitis. 81,88,102 Out of concern for the side effects from these commonly used treatments (Table V), [81][82][83]85,89,92,93,106,107,109,110 some innovative, evolving therapies for cutaneous sarcoidosis have been used and are listed in Table VI. 81,88,93,107,111 There are no powered, randomized, controlled, double-blinded studies published in the literature regarding the treatments for cutaneous sarcoidosis and the best documented evidence is a multitude of case reports and systematic reviews of the available literature.…”
Section: Treatmentsmentioning
confidence: 99%
“…Larger studies are still needed to determine its usefulness in treating skin lesions 81,88. Cyclosporin Thought to suppresses T-cell response, however, its use in treating sarcoidosis is controversial because of conflicting clinical studies that show minimal benefit and worsening of symptoms 81,107,111. Laser therapy Lasers work by debulking granulomas.…”
mentioning
confidence: 99%