Lupus Myocarditis: Initial Presentation and Longterm Outcomes in a Multicentric Series of 29 Patients

Thomas, G.; Aubart, F. Cohen; Chiche, Laurent; Haroche, Julien; Hié, M.; Hervier, B.; Costédoat-Chalumeau, Nathalie; Mazodier, Karine; Ebbo, Mikaël; Cluzel, Philippe; Cordel, N.; Ribes, David; Chastre, Jean; Schleinitz, N.; Veit, V.; Piette, Jean‐Charles; Harlé, Jean‐Robert; Combes, Alain; Amoura, Zahir

doi:10.3899/jrheum.160493

Cited by 88 publications

(81 citation statements)

References 33 publications

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“…It can be the initial cardiac manifestation during the progression of SLE in, particularly, among the untreated patients [32]. A French study showed that myocarditis was the first symptom in 58.6% of SLE patients [33], while 5.7% of Chinese SLE patients suffered from myocarditis in our study. Steroids and cyclophosphamide provide therapy for lupus myocarditis [34,35].…”

Section: Discussionsupporting

confidence: 45%

Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study

et al. 2018

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Objective To investigate cardiac manifestations and the risk factors in Han Chinese patients with systemic lupus erythematosus (SLE). Methods Seven hundred fifty SLE patients who were hospitalized at our department were recruited in the present study. The patients were divided into two groups-those with or without cardiac manifestations. Cardiac manifestations in those SLE patients, such as pericarditis, myocarditis, heart valve disease, arrhythmia, were analyzed. The risk and protective factors of cardiac diseases in patients with SLE, as well as the predictors of mortality, were assessed, respectively. Results In all 750 SLE patients, there were 339 (45.20%) patients suffered from one or more cardiac manifestations, involving pericarditis in 9.5%, myocarditis in 5.7%, heart valve disease in 15.6%, arrhythmia in 16.67%, and cardiovascular diseases (CVD) in 14%. 15.7% of SLE patients were accompanied with pulmonary arterial hypertension (PAH), of which 13.7% were mild, 1.2% were moderate, and 0.8% were severe. No significant differences were found between the two groups in age, disease duration, gender, antibody, and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The incidence of pericarditis, heart valve disease, arrhythmia, and PAH was positively correlated with age. The incidence of arrhythmia, CVD, and PAH was correlated with SLEDAI. PAH and myocarditis were the risk factors of mortality in SLE patients with disease duration ≤ 10 years (P = 0.034 and 0.001, respectively). Conclusion Cardiac involvement is common in Han Chinese SLE patients and associated with age and disease activity. PAH and myocarditis are the risk factors of mortality in SLE.

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Section: Discussionsupporting

confidence: 45%

Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study

et al. 2018

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“…Previous reports showed that prevalence of lupus myocarditis is 5–10% of patients [ 3 , 4 ], and mortality may be as high as 10.3% according to a large case series from Paris [ 6 ]. Although other studies report that concomitant lupus activity in various organ occurs in 97% of the patients with lupus myocarditis [ 7 ], our report provides a rare evidence that lupus myocarditis may be a sole manifestation.…”

Section: Discussionmentioning

confidence: 99%

Lupus myocarditis in an octogenarian patient—a case report

Shemesh

Akel

Feld

et al. 2020

Oxford Medical Case Reports

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Lupus myocarditis is a relatively rare manifestation of systemic lupus erythematosus. The majority of patients who experience myocardial involvement are females of young age. Here, we report a case of an 87-year-old male who was hospitalized because of perimyocarditis 2 weeks after undergoing percutaneous coronary intervention. Despite standard therapy his condition worsened, biomarkers and inflammation indices remained elevated, and pericardial effusion accumulated. The use of cardiac magnetic resonance (CMR) imaging, along with thorough history taking and testing for relevant antibodies allowed to establish the unusual diagnosis of lupus myocaridits. We demonstrate that lupus myocarditis may occur even in elderly males, as supported by characteristic CMR features.

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“…It can be the first manifestation of the disease or it can occur during the follow up, in particular in untreated patients (33). In a recent French series of 29 lupus myocarditis, myocarditis was the first sign of SLE in 58.6% of cases (34). The CMR revealed delayed gadolinium enhancement in 9/13 (69%) patients.…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Myocarditis in auto-immune or auto-inflammatory diseases

Comarmond

Cacoub

2017

Autoimmunity Reviews

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Myocarditis is a major cause of heart disease in young patients and a common precursor of heart failure due to dilated cardiomyopathy. Some auto-immune and/or auto-inflammatory diseases may be accompanied by myocarditis, such as sarcoidosis, Behçet's disease, eosinophilic granulomatosis with polyangiitis, myositis, and systemic lupus erythematosus. However, data concerning myocarditis in such auto-immune and/or auto-inflammatory diseases are sparse. New therapeutic strategies should better target the modulation of the immune system, depending on the phase of the disease and the type of underlying auto-immune and/or auto-inflammatory disease.

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Lupus Myocarditis: Initial Presentation and Longterm Outcomes in a Multicentric Series of 29 Patients

Abstract: LM is a severe manifestation of SLE. It can be the first manifestation of the disease or it can occur during followup, in particular in untreated patients. However, the longterm prognosis is typically positive. Patients with less severe disease exhibited good LVEF recovery without CYC.

Cited by 88 publications

References 33 publications

Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study

Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study

Lupus myocarditis in an octogenarian patient—a case report

Myocarditis in auto-immune or auto-inflammatory diseases

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