2000
DOI: 10.1001/archderm.136.12.1508
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Lupus Erythematosus Associated With Genetically Determined Deficiency of the Second Component of the Complement

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Cited by 33 publications
(36 citation statements)
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“…33,36,37 Although one patient presented low GCN for C4A and C4B genes, the other had at least two copies for both C4A and C4B genes. Interestingly, the patient with concomitant C2 and IgA deficiencies presented two copies for C4A and only one copy for C4B.…”
Section: Discussionmentioning
confidence: 98%
“…33,36,37 Although one patient presented low GCN for C4A and C4B genes, the other had at least two copies for both C4A and C4B genes. Interestingly, the patient with concomitant C2 and IgA deficiencies presented two copies for C4A and only one copy for C4B.…”
Section: Discussionmentioning
confidence: 98%
“…70 C2 deficient lupus patients are more inclined to have cutaneous and articular involvement, but mild or absent pleuropericardial, neurologic or renal involvement. 71 Some C2 deficient patients tend to be susceptible to photosensitivity, produce antiRo autoantibodies and are prone to serious and recurrent infections. 71,72 To date, individuals deficient in C1q carry the highest risk of SLE identified.…”
Section: Complement Componentsmentioning
confidence: 99%
“…71 Some C2 deficient patients tend to be susceptible to photosensitivity, produce antiRo autoantibodies and are prone to serious and recurrent infections. 71,72 To date, individuals deficient in C1q carry the highest risk of SLE identified. Of those individuals who are C1q deficient, more than 92% are affected with SLE.…”
Section: Complement Componentsmentioning
confidence: 99%
“…Immunogenetic factors may be found within the complex of human leukocyte antigens (HLA), mainly for SCLE [36,42,63,64]. Furthermore, genetic deficiencies of various complement factors [65][66][67][68][69], as well as functional polymorphisms of tumor necrosis factor-α [63,64,70], may result in a delayed disposal of apoptotic material. Environmental factors include smoking [71] and various infectious agents of mainly viral origin (cytomegalovirus [CMV] and Epstein-Barr virus [EBV]), as well as UV light [62].…”
Section: Prognosis Of Cutaneous Lupus Erythematosusmentioning
confidence: 99%