Lupus anticoagulant in Nigerian women with preeclampsia

Awodu, OA; Shokunbi, Wuraola A.; Ejele, OA

doi:10.4314/wajm.v22i3.27958

Cited by 7 publications

(9 citation statements)

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“…The apparently normal PT and aPTT results among pre-eclamptics in these studies may be due to the result of the balance between the hypercoagulability of normal pregnancy and the production of coagulation inhibitors which increases in pre-eclampsia 27,29. However, Awodu speculated that the prolonged PT in their pre-eclamptics might be due to quantitative or qualitative abnormalities of factors in the extrinsic pathway of coagulation, while the prolonged aPTT in another study by Awodu might be caused by anti-phospholipid antibodies or lupus anticoagulant 30…”

Section: Discussionmentioning

confidence: 91%

Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria

Oladosu-olayiwola¹,

Olawumi²,

Babatunde³

et al. 2018

Afr H. Sci.

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BackgroundThe hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women.MethodologyThis was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05.ResultsThe mean age of the respondents was 29.9±5.2 years. The median(25th–75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000–1560.000ng/ml), 0.11 (0.065–0,300ng/ml) and 3.65 (2.970–4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000–1030.000ng/ml), 0.05 (0.040–0.090ng/ml and 2.650 (2.125–3.400ng/ml) respectively, p<0.05 each.ConclusionThe abnormal levels of PAI-1, D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.

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Section: Discussionmentioning

confidence: 91%

Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria

Oladosu-olayiwola¹,

Olawumi²,

Babatunde³

et al. 2018

Afr H. Sci.

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“…It is interesting to note that 4/8 patients with thromboembolism had positive lupus anticoagulants. In contrast, positive lupus anticoagulants are found in less than 2% of healthy individuals [48,49]. Epidemiologically, patients with idiopathic pulmonary fibrosis (IPF) have a high incidence of after lung transplantation, suggesting that IPF may be a condition associated with an inherent thrombophilic tendency [50,51].…”

Section: Figurementioning

confidence: 94%

Idiopathic Pulmonary Fibrosis Related to Endothelial Injury and Antiendothelial Cell Antibodies

et al. 2006

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“…[45610] While both assays are effective screening methods, the former compromises sensitivity while the latter is more specific. It is also significant to note that most of the studies were on LAs.…”

Section: Introductionmentioning

confidence: 99%

Antiphospholipid antibodies among pregnant women with recurrent fetal wastage in a tertiary hospital in Northern Nigeria

et al. 2016

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Context:The association between antiphospholipid antibodies (APAs) and pregnancy loss has been established and now considered as a treatable cause of pregnancy loss. Data on the prevalence of APA in patients with recurrent pregnancy loss are scarce in our environment.Aims:To determine the prevalence of APA in pregnant women with and without recurrent fetal wastage.Settings and Design:Antenatal clinic of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. A cross-section analytical study.Subjects and Methods:Eighty-five antenatal patients with recurrent fetal loss (cases) and an equal number of antenatal patients without recurrent fetal loss (control) matched for age were studied. Their sociodemographic data obtained and blood samples analyzed for lupus anticoagulant (LA) using activated partial thromboplastin time, direct Russel's viper venom time, hexagonal phospholipids, and IgG anticardiolipin antibody (ACA) using enzyme-linked immunosorbent assay.Statistical Analysis Used:Data were analyzed with Statistical Package for Social Sciences (version 17) by univariate analysis and Chi-square test.Results:The age range of the patients was 18–42 years with a median of 30 years. The prevalence of APA was 14.1% and 4.7% among the cases and controls, respectively. The prevalence of LA was 7.1% and 1.2% among the cases and controls, respectively, whereas ACA was 8.2% and 3.5%, respectively. However, one of the cases was positive for both APA and ACA, giving a prevalence of 1.2%.Conclusions:The prevalence of APA among antenatal patients with recurrent pregnancy loss was, at least, 3 times higher than that of normal antenatal clients. APA should be included in the investigation protocol of women with recurrent fetal wastages in our setting.

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Lupus anticoagulant in Nigerian women with preeclampsia

Cited by 7 publications

References 0 publications

Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria

Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria

Idiopathic Pulmonary Fibrosis Related to Endothelial Injury and Antiendothelial Cell Antibodies

Antiphospholipid antibodies among pregnant women with recurrent fetal wastage in a tertiary hospital in Northern Nigeria

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