2015
DOI: 10.1097/ccm.0000000000001189
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Abstract: Ventilation with low tidal volumes is associated with a lower risk of development of pulmonary complications in patients without acute respiratory distress syndrome.

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Cited by 210 publications
(137 citation statements)
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References 25 publications
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“…A RCT comparing low tidal volume to high tidal volume in patients without ARDS found that the use of low tidal volume protected against the development of ARDS during the follow-up (28). This finding was confirmed in several meta-analyses (29,30) and individual patient data metaanalysis (31,32). Also, despite these potential benefits, since ARDS is poorly recognized by physicians, the wide adoption of low tidal volume for the ventilation of all critically ill patients is appealing and could avoid the exposure of patients with unrecognized ARDS to higher tidal volumes.…”
supporting
confidence: 63%
“…A RCT comparing low tidal volume to high tidal volume in patients without ARDS found that the use of low tidal volume protected against the development of ARDS during the follow-up (28). This finding was confirmed in several meta-analyses (29,30) and individual patient data metaanalysis (31,32). Also, despite these potential benefits, since ARDS is poorly recognized by physicians, the wide adoption of low tidal volume for the ventilation of all critically ill patients is appealing and could avoid the exposure of patients with unrecognized ARDS to higher tidal volumes.…”
supporting
confidence: 63%
“…Large individual data meta-analyses have reported similar effects of reduced V T and improved outcome in patients without lung injury [15]. A large retrospective study [16] found that Pplat <16 cmH 2 O during surgery was associated with fewer postoperative complications.…”
mentioning
confidence: 99%
“…Recent studies suggest that the preferred strategy in patients at highrisk would be to reduce the incidence of ARDS, using a preemptive mechanical ventilation strategy. This preemptive strategy would apply protective mechanical ventilation as soon as the patient is intubated, before the development of acute lung injury (18). With an ARDS mortality still at ~40%, with no decrease in over 15 years, reducing ARDS incidence is a very appealing approach.…”
mentioning
confidence: 99%