“…A RCT comparing low tidal volume to high tidal volume in patients without ARDS found that the use of low tidal volume protected against the development of ARDS during the follow-up (28). This finding was confirmed in several meta-analyses (29,30) and individual patient data metaanalysis (31,32). Also, despite these potential benefits, since ARDS is poorly recognized by physicians, the wide adoption of low tidal volume for the ventilation of all critically ill patients is appealing and could avoid the exposure of patients with unrecognized ARDS to higher tidal volumes.…”