Lung perfusion scans in patients with congenital heart defects

Abstract

In 63 patients with various congenital heart defects, lung perfusion was evaluated with technetium-99mm macroaggregated albumin. Right lung perfusion abnormalities were documented in 34 patients (54%). A particularly high incidence occurred in patients who had undergone a systemic to pulmonary artery shunt operation as an initial palliative procedure or who had had right ventricular outflow reconstruction and in those with bilateral pulmonary artery stenosis. Serial studies were helpful in evaluating the functional results of different transcatheter interventions for optimizing pulmonary blood flow. The quantitative relative perfusion radionuclide method was a more sensitive means of detecting cases of abnormal lung perfusion than was chest radiology.

Influence of Pulmonary Regurgitation Inequality on Differential Perfusion of the Lungs in Tetralogy of Fallot After Repair

“…Phase-contrast flow measurement has been integrated in comprehensive cardiopulmonary MRI in evaluation of TOF (6,10). From In TOF after repair, it is important to know the differential lung perfusion, because asymmetry of lung perfusion is one of the predictors of outcome and exercise capacity (11)(12)(13)(14). Although the impact of pulmonary regurgitation on right ventricular dysfunction has been extensively investigated, its impact on lung perfusion has not been explored yet.…”

“…Clinical impact. Precise estimation of pulmonary perfusion has gained an increasingly important role in comprehensive evaluation of cardiopulmonary function in TOF after repair (11)(12)(13)(14). Because peripheral pulmonary stenosis occurs not uncommonly over the LPA in repaired TOF, underestimation of differential perfusion of the left lung by conventional PC-MRI method with NFV ratio, as illustrated in Figure 1, would lead to an overestimation of LPA stenosis; as a result, unnecessary invasive procedures such as catheterization and balloon vascular dilatation might be conducted.…”

Pulmonary perfusion scans following transcatheter patent ductus arteriosus closure using the Amplatzer devices

“…Recent studies in adults have shown that the normal distribution in adult population with no cardiac anomalies is 52.5/47.5 (AE2.1%) for right/left lungs [6]. Nonetheless, some studies in children with congenital heart disease found normal blood flow distribution to both lungs in patent ductus arteriosus, although preferential flow to one lung or the other was significant in other defects such as pulmonary stenosis or ventricular septal defects [30][31][32]. Others have reported that some patients with PDA have an inherently preferential blood flow from the right ventricle to right pulmonary artery [33].…”

Practical Indication-Based Pediatric Nuclear Medicine Studies

“…5). 15,16 Ventilation-perfusion scintigraphy Ventilation-perfusion scintigraphy (V/Q) is performed in children with suspected pulmonary thromboembolism, usually in the setting of contraindications to CT angiography, such as contrast allergy or renal disease, or when there are radiation concerns. 17 In repaired congenital diaphragmatic hernia, V/Q scintigraphy is useful to assess ventilation and perfusion abnormalities (Fig.…”