Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective

Dai, Jie; Yang, Ping; Cox, Angela; Jiang, Gening

doi:10.18632/oncotarget.14505

Cited by 43 publications

(32 citation statements)

References 120 publications

(162 reference statements)

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“…Lung cancer research is currently characterized by a tremendous amount of new insights and approaches ranging from genetics [ 1 ] over novel treatment options [ 2 ] to diagnostics [ 3 – 5 ] and prevention [ 6 , 7 ]. In the past two decades, there has been an increased focus on gender differences in health and disease [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Gendermetrics of cancer research: results from a global analysis on lung cancer

et al. 2017

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BackgroundCancer research is critically dependent on a continuous recruitment of junior research staff that devotes its academic life not only to clinical duties but also to basic and translational research. The present study aims to elucidate the success concerning gender equality in cancer research in the last decade (from 2008 to 2016) with lung cancer as the target parameter.Materials and MethodsOn the basis of the Gendermetrics Platform, a total of 19,724 articles related to lung cancer research were analyzed. The key method was the combined analysis of the proportion of female authorships and the female-to-male odds ratio for first, co- and last authorships. The distribution of prestigious authorships was measured by the Prestige Index.Results31.3% of all authorships and 35.2% of the first, 32.2% of the co- and 22.1% of the last authorships were held by women. The corresponding female-to-male odds ratio is 1.22 (CI: 1.18–1.27) for first, 1.19 (CI: 1.16–1.23) for co- and 0.59 (CI: 0.57–0.61) for last authorships. Women are underrepresented at prestigious authorships compared to men (Prestige Index = −0.22). The female underrepresentation accentuates in articles with many authors that attract the highest citation rates.ConclusionsWhile the current system promotes early career promotion of women, men still outnumber women in leadership positions. However, this male-female career dichotomy has been narrowed in the last decade and will likely be further reduced in the next decade.

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Section: Introductionmentioning

confidence: 99%

Gendermetrics of cancer research: results from a global analysis on lung cancer

et al. 2017

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“…Several epidemiologic studies and lung cancer screening trials have shown a two- to four-fold increase in lung cancer risk in patients with COPD in comparison with non-COPD smokers [ 12 ]. This risk is highest when airflow obstruction and emphysema coexist in a patient [ 17 ]. Squamous cell carcinoma in particular is more commonly seen in patients with COPD, and tumor localization strongly associates with areas with the highest degree of emphysema [ 17 ].…”

Section: Aging Lung Diseases May Overlapmentioning

confidence: 99%

“…This risk is highest when airflow obstruction and emphysema coexist in a patient [ 17 ]. Squamous cell carcinoma in particular is more commonly seen in patients with COPD, and tumor localization strongly associates with areas with the highest degree of emphysema [ 17 ].…”

Section: Aging Lung Diseases May Overlapmentioning

confidence: 99%

Trade-offs in aging lung diseases

Moorsel

2018

Current Opinion in Pulmonary Medicine

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Purpose of reviewThe process of aging involves biological changes that increases susceptibility for disease. In the aging lung disease IPF, GWAS studies identified genes associated with risk for disease. Recently, several of these genes were also found to be involved in risk for COPD or lung cancer. This review describes GWAS-derived risk genes for IPF that overlap with risk genes for lung cancer or COPD.Recent findingsRisk genes that overlap between aging lung diseases, include FAM13A, DSP and TERT. Most interestingly, disease predisposing alleles for IPF are opposite to those for COPD or lung cancer. Studies show that the alleles are associated with differential gene expression and with physiological traits in the general population. The opposite allelic effect sizes suggest the presence of trade-offs in the aging lung. For TERT, the trade-off involves cellular senescence versus proliferation and repair. For FAM13A and DSP, trade-offs may involve protection from noxious gases or tissue integrity.SummaryThe overlap in risk genes in aging lung diseases provides evidence that processes associated with FAM13A, DSP and TERT are important for healthy aging. The opposite effect size of the disease risk alleles may represent trade-offs, for which a model involving an apicobasal gene expression gradient is presented.

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“…Lung cancer and COPD are interrelated pulmonary diseases. 10 They share many common risk factors, such as cigarette smoking and other inhalation hazards from occupational, domestic, or outdoor air pollution. 11 – 15 The association between COPD and lung cancer risks has been studied extensively over the last 30 years.…”

Section: Introductionmentioning

confidence: 99%

The link between chronic obstructive pulmonary disease phenotypes and histological subtypes of lung cancer: a case–control study

Wang

Xie

Dou

et al. 2018

COPD

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BackgroundCOPD is considered an independent risk factor for lung cancer. COPD and lung cancer are both very heterogeneous diseases, and the study herein investigates the link between COPD phenotypes and specific histological subtypes of lung cancer.MethodsThis case–control study comprised 2,283 patients with newly diagnosed pathological lung cancer and 2,323 non-lung cancer controls. All participants underwent pulmonary function tests. The diagnosis of COPD was based on Global Initiative for Chronic Obstructive Lung Disease criteria. Subtypes of the two diseases were categorized according to 2015 World Health Organization classification of lung cancer and computer quantification of airway collapse on maximum expiratory flow volume. ORs were estimated using logistic regression analysis.ResultsThe prevalence of COPD was higher (32.8%) in lung cancer patients compared to controls (16.0%). After adjustment for age, sex, body-mass index, and smoking status, the presence of COPD significantly increased the risk of lung cancer (OR 2.88, 95% CI 2.48–3.34) and all common histological subtypes (ORs 2.04–5.26). Both emphysema-predominant and non-emphysema-predominant phenotypes of COPD significantly increased the risk of lung cancer (OR 4.43, 95% CI 2.85–6.88; OR 2.82, 95% CI 2.40–3.31). Higher risk of squamous-cell carcinoma and small-cell lung cancer was observed in patients with the emphysema-predominant than the non-emphysema-predominant phenotype (OR 1.73, 95% CI 1.03–2.89; OR 3.74, 95% CI 1.64–8.53).ConclusionCOPD was an independent risk factor for lung cancer and all common histological subtypes. Both emphysema-predominant and non-emphysema-predominant phenotypes of COPD significantly increased the risk of lung cancer. Relative to non-emphysema-predominant phenotype of COPD, emphysema-predominant phenotype had a higher risk of squamous-cell carcinoma and small-cell lung cancer.

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Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective

Cited by 43 publications

References 120 publications

Gendermetrics of cancer research: results from a global analysis on lung cancer

Gendermetrics of cancer research: results from a global analysis on lung cancer

Trade-offs in aging lung diseases

The link between chronic obstructive pulmonary disease phenotypes and histological subtypes of lung cancer: a case–control study

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Lung cancer and chronic obstructive pulmonary disease: From a clinical perspective

Cited by 43 publications

References 120 publications

Gendermetrics of cancer research: results from a global analysis on lung cancer

Gendermetrics of cancer research: results from a global analysis on lung cancer

Trade-offs in aging lung diseases

The link between chronic obstructive pulmonary disease phenotypes and histological subtypes of lung cancer: a case&ndash;control study

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The link between chronic obstructive pulmonary disease phenotypes and histological subtypes of lung cancer: a case–control study