2015
DOI: 10.1016/j.rppnen.2014.09.009
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Abstract: Pulmonary adenocarcinomas are still in the process of achieving morphological, immunohistochemical and genetic standardization. The ATS/ERS/IASLC proposed classification for lung adenocarcinomas supports the value of the identification of histological patterns, specifically in biopsies.Thirty pulmonary adenocarcinomas were subjected to immunohistochemical study (CK7, CK5, 6, 18, CK20, TTF1, CD56, HER2, EGFR and Ki-67), FISH and PCR followed by sequencing and fragment analysis for EGFR, HER2 and KRAS.Solid patt… Show more

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Cited by 4 publications
(9 citation statements)
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References 56 publications
(47 reference statements)
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“…We verified that generally EGFR mutations were present in all the patterns of the same adenocarcinoma, reinforcing the possibility of mutational status determination in biopsies [47]. Some other authors also identified that the identification of EGFR mutations was independent of the localizations in the primary tumour and concordant with metastasis [80].…”
Section: Doi: 101159/000487440supporting
confidence: 80%
See 3 more Smart Citations
“…We verified that generally EGFR mutations were present in all the patterns of the same adenocarcinoma, reinforcing the possibility of mutational status determination in biopsies [47]. Some other authors also identified that the identification of EGFR mutations was independent of the localizations in the primary tumour and concordant with metastasis [80].…”
Section: Doi: 101159/000487440supporting
confidence: 80%
“…Some other authors also identified that the identification of EGFR mutations was independent of the localizations in the primary tumour and concordant with metastasis [80]. However, we did find some cases where the mutations were not present in all the patterns [47]. We also found cases with harbouring different EGFR mutations in different patterns, nevertheless all mutations were activating mutations [47].…”
Section: Doi: 101159/000487440supporting
confidence: 75%
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“…Mucinous subtypes and solid patterns show lower expression of nuclear TTF1 and higher expression of Ki67, refl ecting probably a particular cell origin and more aggressive biological behaviour and have to be reported as lung adenocarcinomas, avoiding poorly differentiated carcinoma designation. 22 Our results did not indicate signifi cant differences between sensitivity and specifi city of TTF1/NapsinA in both mucinous and non-mucinous adenocarcinomas in the lung and the same mutation frequency of EGFR in mucinous AC -3/21 cases (14.3%) as mutation frequency detected in non-mucinous AC in Bulgarian region -10-15%.…”
Section: Egfr Mutationscontrasting
confidence: 51%